Is Burosumab Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Burosumab? Is Burosumab safe for nursing mother and child? Does Burosumab extracts into breast milk? Does Burosumab has any long term or short term side effects on infants? Can Burosumab influence milk supply or can Burosumab decrease milk supply in lactating mothers?
Answer by DrLact: About Burosumab usage in lactation
No information is available on the clinical use of burosumab alfa during breastfeeding. Because burosumab alfa is a large protein molecule with a molecular weight of about 170,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Burosumab is a human immunoglobulin G1 (IgG1) antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G in mature milk by 60 to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.
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