Is Pegvaliase Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Pegvaliase? Is Pegvaliase safe for nursing mother and child? Does Pegvaliase extracts into breast milk? Does Pegvaliase has any long term or short term side effects on infants? Can Pegvaliase influence milk supply or can Pegvaliase decrease milk supply in lactating mothers?
Answer by DrLact: About Pegvaliase usage in lactation
No information is available on the use of pegvaliase-pqpz during breastfeeding. Absorption of the drug by the infant from breastmilk is unlikely because it is a polypeptide that is probably destroyed in the infant's gastrointestinal tract. Pegvaliase-pqpz may decrease the phenylalanine content of breastmilk. The manufacturer recommends monitoring blood phenylalanine concentrations in breastfeeding women treated with pegvaliase-pqpz.