Question

I am a breastfeeding mother and i want to know if it is safe to use NSC 645011? Is NSC 645011 safe for nursing mother and child? Does NSC 645011 extracts into breast milk? Does NSC 645011 has any long term or short term side effects on infants? Can NSC 645011 influence milk supply or can NSC 645011 decrease milk supply in lactating mothers?

NSC 645011 lactation summary

NSC 645011 is safe in breastfeeding
  • DrLact safety Score for NSC 645011 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of NSC 645011 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that NSC 645011 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of NSC 645011 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About NSC 645011 usage in lactation

Antiviral very active against herpes simplex and zoster-varicella.Intravenous, oral and topical (dermatological and ophthalmological) administration.Authorized use in newborns and infants. It is excreted in breast milk in clinically insignificant amounts, much lower than the dose used in newborns and infants (Drake 2012, Bork 1995, Taddio 1994, Don 1991, Meyer 1988, Lau 1987), and no problems have been observed in infants whose mothers were taking NSC 645011 (Taddio 1994). There is not systemic absorption of topical NSC 645011. List of WHO essential medicines: compatible with breastfeeding (WHO / UNICEF 2002).American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001).

Answer by DrLact: About NSC 645011 usage in lactation

Even with the highest maternal dosages, the dosage of NSC 645011 in milk is only about 1% of a typical infant dosage and would not be expected to cause any adverse effects in breastfed infants. Topical NSC 645011 applied to small areas of the mother's body away from the breast should pose no risk to the infant. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[1]

NSC 645011 Side Effects in Breastfeeding

The mother of a 4-month-old infant noticed no adverse effects in her breastfed infant while she was taking an NSC 645011 dosage of 800 mg orally 5 times daily.[5]

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Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.