Question

I am a breastfeeding mother and i want to know if it is safe to use Pibrentasvir? Is Pibrentasvir safe for nursing mother and child? Does Pibrentasvir extracts into breast milk? Does Pibrentasvir has any long term or short term side effects on infants? Can Pibrentasvir influence milk supply or can Pibrentasvir decrease milk supply in lactating mothers?

Answer by DrLact: About Pibrentasvir usage in lactation

Pibrentasvir has not been studied in nursing mothers being treated for hepatitis C infection. Because it is >99.9% bound to maternal plasma proteins, amounts in breastmilk are likely to be very low. If pibrentasvir alone or in combination with glecaprevir (Mavyret) is required by the mother, it is not a reason to discontinue breastfeeding. Hepatitis C is not transmitted through breastmilk[1][2] and breastmilk has been shown to inactivate hepatitis C virus (HCV).[3][4] However, the Centers for Disease Control recommends that mothers with HCV infection should consider abstaining from breastfeeding if their nipples are cracked or bleeding. It is not clear if this warning would apply to mothers who are being treated for hepatitis C. Infants born to mothers with HCV infection should be tested for HCV infection; because maternal antibody is present for the first 18 months of life and before the infant mounts an immunologic response, nucleic acid testing is recommended.[1][2]
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