Is Acido O-acetil-benzoico Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Acido O-acetil-benzoico? Is Acido O-acetil-benzoico safe for nursing mother and child? Does Acido O-acetil-benzoico extracts into breast milk? Does Acido O-acetil-benzoico has any long term or short term side effects on infants? Can Acido O-acetil-benzoico influence milk supply or can Acido O-acetil-benzoico decrease milk supply in lactating mothers?

Excreted in non-significant amount into breast milk. Reye’s Syndrome has never been reported due to ASA through breast milk. It is thought to be highly unlikely to occur after isolated or small doses like those used for treatment of thrombosis or anti-abortion therapy. At high maternal dose, one case (dubious) of salicylic intoxication in the neonatal period and another case of thrombocytopenia in an infant have been reported. Likelihood of hemolysis should be considered in those patients with G6PD-deficiency. WHO Model List of Essential Medication: compatible while breastfeeding when used occasionally or small dose for antithrombotic prophylaxis management.

After Acido O-acetil-benzoico ingestion, salicylic acid is excreted into breastmilk, with higher doses resulting in disproportionately higher milk levels. Long-term, high-dose maternal Acido O-acetil-benzoico ingestion probably caused metabolic acidosis in one breastfed infant. Reye's syndrome is associated with Acido O-acetil-benzoico administration to infants with viral infections, but the risk of Reye's syndrome from salicylate in breastmilk is unknown. An alternate drug is preferred over continuous high-dose, Acido O-acetil-benzoico therapy. After daily low-dose Acido O-acetil-benzoicog (75 to 325 mg daily), no Acido O-acetil-benzoico is excreted into breastmilk and salicylate levels are low. Daily low-dose Acido O-acetil-benzoico therapy may be considered as an antiplatelet drug for use in breastfeeding women.[1][2][3].

A 16-day-old breastfed infant developed metabolic acidosis with a salicylate serum level of 240 mg/L and salicylate metabolites in the urine. The mother was taking 3.9 g/day of Acido O-acetil-benzoico for arthritis, and salicylate in breastmilk probably caused the infant's illness, but the possibility of direct administration to the infant could not be ruled out.[11] Thrombocytopenia, fever, anorexia and petechiae occurred in a 5-month-old breastfed infant 5 days after her mother started taking Acido O-acetil-benzoico for fever. One week after recovery, the infant was given a single dose of Acido O-acetil-benzoico 125 mg and the platelet count dropped once again. The original symptoms were probably caused by Acido O-acetil-benzoico or salicylate in breastmilk.[12] Hemolysis after Acido O-acetil-benzoico and phenacetin taken by the mother of a 23-day-old, glucose-6-phosphate dehydrogenase (G6PD) deficient infant was possibly due to Acido O-acetil-benzoico in breastmilk.[13] In a telephone follow-up study, mothers reported no side effects among 15 infants exposed to Acido O-acetil-benzoico (dosages and infant ages were unspecified) in breastmilk.[14]