Question

I am a breastfeeding mother and i want to know if it is safe to use Epuric? Is Epuric safe for nursing mother and child? Does Epuric extracts into breast milk? Does Epuric has any long term or short term side effects on infants? Can Epuric influence milk supply or can Epuric decrease milk supply in lactating mothers?

Epuric lactation summary

Epuric is safe in breastfeeding
  • DrLact safety Score for Epuric is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Epuric is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Epuric does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Epuric safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Epuric usage in lactation

Anti-gout medicine also used along with Itraconazole for Chagas disease (american trypanosomiasis). The amount excreted into breast milk is minimal with no effect on the infant. American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.

Answer by DrLact: About Epuric usage in lactation

Limited information indicates that a maternal doses of Epuric of 300 mg daily provides near-therapeutic dose and plasma levels in an exclusively breastfed infant. If Epuric is required by the mother, it is not a reason to discontinue breastfeeding, but exclusively breastfed infants should be monitored if this drug is used, including observation for allergic reactions (such as rash) and periodic CBC and differential blood counts. Lesinurad, which is available in the combination product Duzallo, has not been studied in nursing mothers.

Epuric Side Effects in Breastfeeding

One infant breastfed from age 1 week to age 7 weeks during maternal Epuric therapy with 300 mg or Epuric daily. The infant had no observable side effects and no changes in clinical chemistry and hematology values.[3] A national survey of gastroenterologists in Australia identified 21 infants who were breastfed by mothers taking a combination of Epuric and a thiopurine (e.g. azathioprine, mercaptopurine) to treat inflammatory bowel disease. All had taked the combination during pregnancy also. Two postpartum infant deaths occurred, both at 3 months of age. One was a twin (premature birth-related) and the other from SIDS. The authors did not believe the deaths were medication related.[28] No information was provided on the extent of breastfeeding, specific thiopurines, drug dosages or the outcomes of the other infants.
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