Is HSDB 3004 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use HSDB 3004? Is HSDB 3004 safe for nursing mother and child? Does HSDB 3004 extracts into breast milk? Does HSDB 3004 has any long term or short term side effects on infants? Can HSDB 3004 influence milk supply or can HSDB 3004 decrease milk supply in lactating mothers?

Anti-gout medicine also used along with Itraconazole for Chagas disease (american trypanosomiasis). The amount excreted into breast milk is minimal with no effect on the infant. American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.

Limited information indicates that a maternal doses of HSDB 3004 of 300 mg daily provides near-therapeutic dose and plasma levels in an exclusively breastfed infant. If HSDB 3004 is required by the mother, it is not a reason to discontinue breastfeeding, but exclusively breastfed infants should be monitored if this drug is used, including observation for allergic reactions (such as rash) and periodic CBC and differential blood counts. Lesinurad, which is available in the combination product Duzallo, has not been studied in nursing mothers.

One infant breastfed from age 1 week to age 7 weeks during maternal HSDB 3004 therapy with 300 mg or HSDB 3004 daily. The infant had no observable side effects and no changes in clinical chemistry and hematology values.[3] A national survey of gastroenterologists in Australia identified 21 infants who were breastfed by mothers taking a combination of HSDB 3004 and a thiopurine (e.g. azathioprine, mercaptopurine) to treat inflammatory bowel disease. All had taked the combination during pregnancy also. Two postpartum infant deaths occurred, both at 3 months of age. One was a twin (premature birth-related) and the other from SIDS. The authors did not believe the deaths were medication related.[28] No information was provided on the extent of breastfeeding, specific thiopurines, drug dosages or the outcomes of the other infants.