Is UNII-63CZ7GJN5I Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use UNII-63CZ7GJN5I? Is UNII-63CZ7GJN5I safe for nursing mother and child? Does UNII-63CZ7GJN5I extracts into breast milk? Does UNII-63CZ7GJN5I has any long term or short term side effects on infants? Can UNII-63CZ7GJN5I influence milk supply or can UNII-63CZ7GJN5I decrease milk supply in lactating mothers?
UNII-63CZ7GJN5I lactation summary
- DrLact safety Score for UNII-63CZ7GJN5I is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of UNII-63CZ7GJN5I is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that UNII-63CZ7GJN5I does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of UNII-63CZ7GJN5I safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About UNII-63CZ7GJN5I usage in lactation
Anti-gout medicine also used along with Itraconazole for Chagas disease (american trypanosomiasis). The amount excreted into breast milk is minimal with no effect on the infant. American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.
Answer by DrLact: About UNII-63CZ7GJN5I usage in lactation
Limited information indicates that a maternal doses of UNII-63CZ7GJN5I of 300 mg daily provides near-therapeutic dose and plasma levels in an exclusively breastfed infant. If UNII-63CZ7GJN5I is required by the mother, it is not a reason to discontinue breastfeeding, but exclusively breastfed infants should be monitored if this drug is used, including observation for allergic reactions (such as rash) and periodic CBC and differential blood counts. Lesinurad, which is available in the combination product Duzallo, has not been studied in nursing mothers.
UNII-63CZ7GJN5I Side Effects in Breastfeeding
One infant breastfed from age 1 week to age 7 weeks during maternal UNII-63CZ7GJN5I therapy with 300 mg or UNII-63CZ7GJN5I daily. The infant had no observable side effects and no changes in clinical chemistry and hematology values.[3] A national survey of gastroenterologists in Australia identified 21 infants who were breastfed by mothers taking a combination of UNII-63CZ7GJN5I and a thiopurine (e.g. azathioprine, mercaptopurine) to treat inflammatory bowel disease. All had taked the combination during pregnancy also. Two postpartum infant deaths occurred, both at 3 months of age. One was a twin (premature birth-related) and the other from SIDS. The authors did not believe the deaths were medication related.[28] No information was provided on the extent of breastfeeding, specific thiopurines, drug dosages or the outcomes of the other infants.
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