Is Topotecan Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Topotecan? Is Topotecan safe for nursing mother and child? Does Topotecan extracts into breast milk? Does Topotecan has any long term or short term side effects on infants? Can Topotecan influence milk supply or can Topotecan decrease milk supply in lactating mothers?
Answer by DrLact: About Topotecan usage in lactation
Most sources consider breastfeeding to be contraindicated during maternal high-dose antineoplastic drug therapy. The manufacturer recommends that women not breastfeed during treatment with topotecan and for 1 week after the last dose. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[1] Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.[2]
Alternate Drugs
Alemtuzumab(Low Risk)
Nivolumab(Unsafe)
Doxorubicin(Dangerous)
Vinblastine(Dangerous)
Docetaxel(Dangerous)
Cyclophosphamide(Dangerous)
Rituximab(Low Risk)
Bleomycin(Dangerous)
Cisplatin(Unsafe)
Bevacizumab(Low Risk)
Pazopanib(Unsafe)
Vinorelbine(Dangerous)
Busulfan(Dangerous)
Dacarbazine(Dangerous)
Trastuzumab(Unsafe)
Imatinib(Unsafe)
Thioguanine(Dangerous)
Cladribine(Dangerous)
Letrozole(Dangerous)
Azelaic Acid(Safe)
Erlotinib(Unsafe)
Exemestane(Dangerous)
Dasatinib(Unsafe)
Vincristine(Dangerous)
Dactinomycin(Dangerous)
Nilotinib(Unsafe)
Tamoxifen(Dangerous)
Ipilimumab(Unsafe)
Mitoxantrone(Dangerous)
Cetuximab(Unsafe)
Mercaptopurine(Safe)
Carboplatin(Dangerous)
Paclitaxel(Dangerous)
Hydroxyurea(Low Risk)
Fluorouracil(Dangerous)
Etoposide(Dangerous)
Gemcitabine(Dangerous)