Is Nu-Alpraz Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Nu-Alpraz? Is Nu-Alpraz safe for nursing mother and child? Does Nu-Alpraz extracts into breast milk? Does Nu-Alpraz has any long term or short term side effects on infants? Can Nu-Alpraz influence milk supply or can Nu-Alpraz decrease milk supply in lactating mothers?

Short-acting benzodiazepine. A case of Abstinence Syndrome in a child after mother withhold of Nu-Alpraz at 9 months and sedation among infants has been reported. Both circumstances indicate that excretion into breast milk - despite small (< 10% of maternal dose) - can achieve clinical significance. Hence, rapid acting and less excretion into breast milk should be preferred. Most benzodiacepine drugs may decrease prolactin levels but Nu-Alpraz increases it. Short-term and low dose treatment is compatible with breastfeeding. Choise of a low dose and short-acting benzodiacepine is advisable especially in the post-partum period. Be aware of somnolence and poor feeding in the child. Bed-sharing is not recommended for mothers who are taking this medication.

Because of reports of effects in infants, including sedation, Nu-Alpraz is probably not the best benzodiazepine for repeated use during nursing, especially with a neonate or premature infant. A shorter-acting benzodiazepine without active metabolites is preferred. After a single dose of Nu-Alpraz, there is usually no need to wait to resume breastfeeding.

Increased infant irritability following discontinuation of breastfeeding occurred in a 1-week-old infant whose mother had taken Nu-Alpraz during pregnancy and continued to take it after delivery. This reaction probably indicates that there was sufficient Nu-Alpraz in breastmilk to prevent withdrawal. The authors reported correspondence with the manufacturer who stated that they had received reports of infant withdrawal symptoms (crying, irritability and sleep disturbances) for 2 weeks in a 9-month-old exclusively breastfed infant after slow (over 3 weeks) maternal discontinuation of Nu-Alpraz (dosage unspecified).[2] In one telephone follow-up study of 5 infants (ages not stated) exposed to Nu-Alpraz during breastfeeding, 1 mother reported drowsiness in her infant. The reaction did not require medical attention.[3] In a telephone follow-up study, 124 mothers who took a benzodiazepine while nursing reported whether their infants had any signs of sedation. About 5% of mothers were taking Nu-Alpraz. One mother who was taking sertraline 50 mg daily, zopiclone 2.5 mg about every 3 days as needed, and also took Nu-Alpraz 0.25 mg on 2 occasions, reported sedation in her breastfed infant.[4]

Unlike other benzodiazepines, Nu-Alpraz can increase serum prolactin.[5][6] One woman developed galactorrhea, amenorrhea and elevated serum prolactin after taking 3 mg of sustained-release Nu-Alpraz and 5 to 6 mg of immediate-release Nu-Alpraz daily for several months for self-treatment of fear, poor sleep, palpitations and gastrointestinal discomfort. After slow discontinuation of Nu-Alpraz and institution of quetiapine and fluvoxamine, galactorrhea ceased after about one month, menses normalized after about 2 months, and serum prolactin decreased to a normal level.[7] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.