Question

I am a breastfeeding mother and i want to know if it is safe to use Fremanezumab? Is Fremanezumab safe for nursing mother and child? Does Fremanezumab extracts into breast milk? Does Fremanezumab has any long term or short term side effects on infants? Can Fremanezumab influence milk supply or can Fremanezumab decrease milk supply in lactating mothers?

Answer by DrLact: About Fremanezumab usage in lactation

No information is available on the clinical use of fremanezumab during breastfeeding. Because fremanezumab is a large protein molecule with a molecular weight of about 148,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Fremanezumab is a human immunoglobulin G2 (IgG2) delta a/kappa antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG2 activity decreasing by about 50%.[3] None of the studies measured IgG activity.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.