Is Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl isopropylcarbamate Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl isopropylcarbamate? Is Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl isopropylcarbamate safe for nursing mother and child? Does Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl isopropylcarbamate extracts into breast milk? Does Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl isopropylcarbamate has any long term or short term side effects on infants? Can Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl isopropylcarbamate influence milk supply or can Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl isopropylcarbamate decrease milk supply in lactating mothers?

Skeletal muscle relaxant with sedative effects on the central nervous system. It is metabolized to meprobamate.Indicated on low back pain. It is excreted into breast milk in a clinically non-significant amount (Nordeng 2001, Bailey 2002, Briggs 2008) without problems being observed on infants whose mothers were receiving this medication, (Nordeng 2001), except for a mild sedation with higher maternal drug doses (Briggs 2008) .Plasma levels in the infant were undetectable (Briggs 2008). Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl isopropylcarbamate use increases the risk of abuse and addictive behavior, intoxication and possible psychomotor impairment (Bailey 2002, EMA 2007) being such a reason to be withdrawn from the market in some countries. The European Medicines Agency (EMA) has recommended to withhold authorizations for marketing of medicines that contains Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl isopropylcarbamate (EMA 2007, Reeves 2012, Bramases 2012). If administered during breastfeeding, it is advisable to use a minimum effective dose and monitor a possible sedation on the infant and an inadequate milk production (Sachs 2013).

If Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl isopropylcarbamate is required by the mother, it is not necessarily a reason to discontinue breastfeeding. Slight sedation has occurred in a breastfed newborn infant who was exposed during pregnancy and lactation; sedation might be more pronounced in newborns who are exposed for the first time during nursing. Other agents may be preferred, especially while nursing a newborn or preterm infant, or when other drugs that can cause sedation are used simultaneously.

A mother taking Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl isopropylcarbamate 700 mg plus propoxyphene 70 mg and acetaminophen 900 mg 3 times daily and partially breastfeeding her infant noticed no unusual behavior or adverse reactions in her infant. The infant grew normally and at 6 months of age, examination by a pediatrician found normal psychomotor development.[1] A mother took Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl isopropylcarbamate 700 mg orally four times daily at 4- to 6-hour intervals during pregnancy and while exclusively nursing her newborn infant. Slight sedation of the infant was noted during the first month of life.[3]