Is Isopropyl meprobamate Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Isopropyl meprobamate? Is Isopropyl meprobamate safe for nursing mother and child? Does Isopropyl meprobamate extracts into breast milk? Does Isopropyl meprobamate has any long term or short term side effects on infants? Can Isopropyl meprobamate influence milk supply or can Isopropyl meprobamate decrease milk supply in lactating mothers?

Skeletal muscle relaxant with sedative effects on the central nervous system. It is metabolized to meprobamate.Indicated on low back pain. It is excreted into breast milk in a clinically non-significant amount (Nordeng 2001, Bailey 2002, Briggs 2008) without problems being observed on infants whose mothers were receiving this medication, (Nordeng 2001), except for a mild sedation with higher maternal drug doses (Briggs 2008) .Plasma levels in the infant were undetectable (Briggs 2008). Isopropyl meprobamate use increases the risk of abuse and addictive behavior, intoxication and possible psychomotor impairment (Bailey 2002, EMA 2007) being such a reason to be withdrawn from the market in some countries. The European Medicines Agency (EMA) has recommended to withhold authorizations for marketing of medicines that contains Isopropyl meprobamate (EMA 2007, Reeves 2012, Bramases 2012). If administered during breastfeeding, it is advisable to use a minimum effective dose and monitor a possible sedation on the infant and an inadequate milk production (Sachs 2013).

If Isopropyl meprobamate is required by the mother, it is not necessarily a reason to discontinue breastfeeding. Slight sedation has occurred in a breastfed newborn infant who was exposed during pregnancy and lactation; sedation might be more pronounced in newborns who are exposed for the first time during nursing. Other agents may be preferred, especially while nursing a newborn or preterm infant, or when other drugs that can cause sedation are used simultaneously.

A mother taking Isopropyl meprobamate 700 mg plus propoxyphene 70 mg and acetaminophen 900 mg 3 times daily and partially breastfeeding her infant noticed no unusual behavior or adverse reactions in her infant. The infant grew normally and at 6 months of age, examination by a pediatrician found normal psychomotor development.[1] A mother took Isopropyl meprobamate 700 mg orally four times daily at 4- to 6-hour intervals during pregnancy and while exclusively nursing her newborn infant. Slight sedation of the infant was noted during the first month of life.[3]