Is CB 4306 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use CB 4306? Is CB 4306 safe for nursing mother and child? Does CB 4306 extracts into breast milk? Does CB 4306 has any long term or short term side effects on infants? Can CB 4306 influence milk supply or can CB 4306 decrease milk supply in lactating mothers?

Long-acting benzodiazepine. Most of the CB 4306 is metabolized to N-desmethyldiazepam (nordiazepam) which is the active metabolite of diazepam. It is excreted in breast milk in clinically insignificant amounts (Rey 1979). Sedation has been observed in infants whose mothers were taking diazepam (Wesson 1985). Due to the lack of publications on this subject, until more information is known about this drug in relation to breastfeeding, safer known alternatives are preferred, especially in the neonatal period and in case of prematurity (McElhatton 1994). Occasional and low-dose use of benzodiazepines is compatible with breastfeeding. It is advisable to choose short-duration benzodiazepines and to use the minimum effective dose. Monitor drowsiness and the adequate feeding of the infant (Kanto 1982). It is not recommended to co-sleep with the baby if you are taking this medication (UNICEF 2013, Landa 2012, ABM 2008, UNICEF 2006).

CB 4306 is excreted into breastmilk and appears to accumulate in the serum of breastfed infants. Because the half-life of CB 4306 and its active metabolite are long, timing breastfeeding with respect to the dose is of little or no benefit in reducing infant exposure. Other agents may be preferred, especially while nursing a newborn or preterm infant.

Sedation in infants has been reported during maternal use of diazepam which has nordiazepam as its active metabolite.[3][4] Concern has also been expressed that nordiazepam may compete with bilirubin for hepatic glucuronide conjugation in the neonate.[2]