Is Nimesulide Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Nimesulide? Is Nimesulide safe for nursing mother and child? Does Nimesulide extracts into breast milk? Does Nimesulide has any long term or short term side effects on infants? Can Nimesulide influence milk supply or can Nimesulide decrease milk supply in lactating mothers?

• DrLact safety Score for Nimesulide is 5 out of 8 which is considered Unsafe as per our analyses.
• A safety Score of 5 indicates that usage of Nimesulide may cause serious side effects in breastfed baby.
• Our study of different scientific research indicates that Nimesulide may cause moderate to high side effects or may affect milk supply in lactating mother.
• Our suggestion is to use safer alternate options rather than using Nimesulide .
• It is recommended to evaluate the advantage of not breastfeeding while using Nimesulide Vs not using Nimesulide And continue breastfeeding.
• While using Nimesulide Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
• Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Drug approval was cautionary withheld in many countries since 2002 because of increase risk of severe liver toxicity. The FDA never approved it for use in the USA. The EMA (European Drug Agency) introduced limitations for use by narrowing indication profile, shortening duration of treatment, age restriction for younger than 12 year, and avoiding it in pregnancy and breastfeeding. Latest update failed to find relevant data on breastfeeding. Its high molecular weight and plasma protein binding make excretion into breast milk unlikely. However, anti-inflammatory drugs that are known to be safer for both the mother and the infant should be preferred.