Is Seduksen Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Seduksen? Is Seduksen safe for nursing mother and child? Does Seduksen extracts into breast milk? Does Seduksen has any long term or short term side effects on infants? Can Seduksen influence milk supply or can Seduksen decrease milk supply in lactating mothers?

It is a long-acting Benzodiazepine. Low excreted into breast milk. However, it may cause sedation and poor suction reflex in the infant mostly because of large or repetitive use in the newborn period. Low dose and short-term use is usually compatible with breastfeeding. Choose a short-acting and minimal effective drug dose specially when nursing a newborn. Watch out for somnolence and poor feeding of the infant. Bed-sharing is not recommended for mothers who are taking this medication.

Seduksen is excreted into breastmilk and it and its active metabolite, norSeduksen, accumulate in the serum of breastfed infants with repeated doses. Because the half-life of Seduksen and norSeduksen are long, timing breastfeeding with respect to the dose is of little or no benefit in reducing infant exposure. Other agents are preferred, especially while nursing a newborn or preterm infant. After a single dose of Seduksen, as for sedation before a procedure, there is usually no need to wait to resume breastfeeding, although with a newborn or preterm infant, a cautious approach would be to wait a period of 6 to 8 hours before resuming nursing.

Three infants were breastfed from birth while their mothers were receiving Seduksen 10 mg 3 times daily. The authors noticed no lethargy or hypoventilation in the infants during the 6-day observation period. The authors expressed concern that norSeduksen may compete with bilirubin for hepatic glucuronide conjugation in the neonate.[1] A nursing mother was given Seduksen 10 mg orally 3 times a day beginning on day 5 postpartum. Weight loss, lethargy and an EEG consistent with sedative effect in her 8-day-old was probably caused by Seduksen or its metabolites in breastmilk.[7] Of 8 infants breastfed from birth during maternal Seduksen therapy (dosages unspecified), 3 had mild jaundice during the first few days postpartum, although this was not thought by the authors to be unusual.[8] Sedation was reported in the breastfed newborn infant of a mother taking oral Seduksen 6 to 10 mg daily if the infant was nursed within a few hours of a dose, but not if she nursed 8 or more hours after a dose. Infant sedation was probably caused by Seduksen and its major metabolite in breastmilk.[4] In a telephone follow-up study, 124 mothers who took a benzodiazepine while nursing reported whether their infants had any signs of sedation. About 10% of mothers took Seduksen while breastfeeding and none reported sedation in her infant.[9] In a longitudinal study of women taking medications during breastfeeding, some mothers who were taking Seduksen reported discontinuing breastfeeding because of drowsiness in their breastfed infants.[10]