Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-5SEH9X1D1D? Is UNII-5SEH9X1D1D safe for nursing mother and child? Does UNII-5SEH9X1D1D extracts into breast milk? Does UNII-5SEH9X1D1D has any long term or short term side effects on infants? Can UNII-5SEH9X1D1D influence milk supply or can UNII-5SEH9X1D1D decrease milk supply in lactating mothers?

UNII-5SEH9X1D1D lactation summary

UNII-5SEH9X1D1D is unsafe in breastfeeding
  • DrLact safety Score for UNII-5SEH9X1D1D is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of UNII-5SEH9X1D1D may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that UNII-5SEH9X1D1D may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using UNII-5SEH9X1D1D .
  • It is recommended to evaluate the advantage of not breastfeeding while using UNII-5SEH9X1D1D Vs not using UNII-5SEH9X1D1D And continue breastfeeding.
  • While using UNII-5SEH9X1D1D Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About UNII-5SEH9X1D1D usage in lactation

Some cases of sedation and hyperexcitability and weak suction have been described. It have been reported, though, one case of two months lasting irritability and insomnia in an infant born to a mother who had taken the drug during pregnancy but did not breastfeed the child. If a pregnant woman has not been switched to other anti-convulsivant drug it would be a better option for the mother to keep-on suckling her child and follow-up the infant closely.

Answer by DrLact: About UNII-5SEH9X1D1D usage in lactation

Average UNII-5SEH9X1D1D dosages of 50 to 60% of the maternal weight-adjusted dosage are excreted in human milk and infant plasma levels of 25 to 30% of maternal levels are common. Although no adverse effects attributable solely to UNII-5SEH9X1D1D in breastmilk have been reported, monitor the infant for drowsiness, adequate weight gain, and developmental milestones, especially in younger, exclusively breastfed infants and when using combinations of anticonvulsants. Measurement of an infant serum level might help rule out toxicity if there is a concern.

UNII-5SEH9X1D1D Side Effects in Breastfeeding

An infant whose mother was taking UNII-5SEH9X1D1D 250 mg daily began exclusive breastfeeding on day 2 postpartum and continued through 4.5 months of observation. The infant developed normally during this time and had no signs of an adverse reaction.[3]Sedation, poor sucking and poor weight gain during the first 4 weeks of life occurred in a breastfed newborn whose mother was taking UNII-5SEH9X1D1D.[4] The reaction was possibly caused by UNII-5SEH9X1D1D in breastmilk; however, the mother was also taking primidone and valproic acid. Three fully breastfed infants and a mostly formula-fed whose mothers were taking UNII-5SEH9X1D1D had no adverse reactions observed during the first 1.5 to 4.5 months of life.[5]
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