Question

I am a breastfeeding mother and i want to know if it is safe to use NSC 19044? Is NSC 19044 safe for nursing mother and child? Does NSC 19044 extracts into breast milk? Does NSC 19044 has any long term or short term side effects on infants? Can NSC 19044 influence milk supply or can NSC 19044 decrease milk supply in lactating mothers?

NSC 19044 lactation summary

NSC 19044 usage has low risk in breastfeeding
  • DrLact safety Score for NSC 19044 is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of NSC 19044 may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that NSC 19044 may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of NSC 19044 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using NSC 19044 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About NSC 19044 usage in lactation

Not commercially available in Spain

Answer by DrLact: About NSC 19044 usage in lactation

NSC 19044 is a opioid narcotic. BenzNSC 19044 is a NSC 19044 prodrug that is rapidly converted into NSC 19044 in the gastrointestinal tract. Maternal use of oral narcotics during breastfeeding can cause infant drowsiness, central nervous system depression and even death. Newborn infants seem to be particularly sensitive to the effects of even small dosages of narcotic analgesics. Once the mother's milk comes in, it is best to provide pain control with a nonnarcotic analgesic and limit maternal intake of oral NSC 19044 to a few days at a maximum dosage of 30 mg daily with close infant monitoring. If the baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing difficulties, or limpness, a physician should be contacted immediately.

NSC 19044 Side Effects in Breastfeeding

The 18-day-old infant of a breastfeeding mother became groggy and "slept for most of the day" while the mother was taking 20 mg of oral NSC 19044 combined with 1300 mg of acetaminophen every 4 hours for painful nipple candidiasis and mastitis. The mother decreased her dose by one-half and the infant apparently no longer experienced grogginess or hypersomnolence.[3] The infant's symptoms were probably due to the maternal NSC 19044. A 5-week-old breastfed infant became cyanotic and required mouth-to-mouth resuscitation and intubation. The infant's urine was positive for opioids and the infant responded positively to naloxone; the level of consciousness improved over 2 days and extubation was accomplished. The infant's mother admitted to taking a NSC 19044-acetaminophen combination product and methadone that had been prescribed for migraine headache before she was breastfeeding.[4] The infant's symptoms were probably due to the maternal opiate use.

NSC 19044 Possible Effects in Breastfeeding

Narcotics can increase serum prolactin.[5] However, the prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.