Question

I am a breastfeeding mother and i want to know if it is safe to use 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one? Is 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one safe for nursing mother and child? Does 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one extracts into breast milk? Does 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one has any long term or short term side effects on infants? Can 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one influence milk supply or can 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one decrease milk supply in lactating mothers?

7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one lactation summary

7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one is safe in breastfeeding
  • DrLact safety Score for 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one usage in lactation

Short-acting Benzodiazepine drug. Excretion into breast milk is non-significant (Whitelaw 1981, Summerfield 1985 , Lemmer 2007). No harmful effects on breastfed infants have appeared at a normal dose (Kelly 2012). Unusual and low doses of benzodiazepine are compatible with breastfeeding. Use a short-acting benzodiazepine and minimal effective dose as possible mostly in neonatal period. Follow-up for sedation and feeding ability of the infant. Bed-sharing is not recommended for mothers who are taking this medication.

Answer by DrLact: About 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one usage in lactation

7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one has low levels in breastmilk, a short half-life relative to many other benzodiazepines, and is safely administered directly to infants. Evidence from nursing mothers indicates that 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one does not cause any adverse effects in breastfed infants with usual maternal dosages. No special precautions are required.

7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one Side Effects in Breastfeeding

The newborn infant of a mother taking 2.5 mg of 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one orally twice daily for 5 days after delivery showed no signs of sedation.[2] In a telephone follow-up study, 124 mothers who took a benzodiazepine while nursing reported whether their infants had any signs of sedation. Sixty-four mothers took 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one while breastfeeding and none reported sedation in her infant.[4]

Alternate Drugs

Quazepam(Unsafe)
Clorazepate(Low Risk)
Oxazepam(Safe)
Alprazolam(Low Risk)
Midazolam(Safe)
Lorazepam(Safe)
Temazepam(Low Risk)
Meprobamate(Low Risk)
Diazepam(Low Risk)
Nitrazepam(Low Risk)
Clorazepate(Low Risk)
Clonazepam(Low Risk)
Oxazepam(Safe)
Alprazolam(Low Risk)
Midazolam(Safe)
Clobazam(Low Risk)
Lorazepam(Safe)
Estazolam(Low Risk)
Temazepam(Low Risk)
Flurazepam(Unsafe)
Diazepam(Low Risk)
Nitrazepam(Low Risk)
Quazepam(Unsafe)
Nitrazepam(Low Risk)
Quazepam(Unsafe)
Butabarbital(Low Risk)
Phenobarbital(Low Risk)
Pentobarbital(Low Risk)
Clorazepate(Low Risk)
Secobarbital(Low Risk)
Propofol(Safe)
Oxazepam(Safe)
Alprazolam(Low Risk)
Ketamine(Low Risk)
Chloral Hydrate(Low Risk)
Midazolam(Safe)
Zolpidem(Safe)
Estazolam(Low Risk)
Zaleplon(Safe)
Triazolam(Low Risk)
Flurazepam(Unsafe)
Lorazepam(Safe)
Eszopiclone(Low Risk)
Sodium Oxybate(Low Risk)
Meprobamate(Low Risk)
Temazepam(Low Risk)
Butalbital(Low Risk)
Diazepam(Low Risk)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.