Is HSDB 3140 Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use HSDB 3140? Is HSDB 3140 safe for nursing mother and child? Does HSDB 3140 extracts into breast milk? Does HSDB 3140 has any long term or short term side effects on infants? Can HSDB 3140 influence milk supply or can HSDB 3140 decrease milk supply in lactating mothers?

HSDB 3140 lactation summary

DrLact safety Score for HSDB 3140 is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of HSDB 3140 is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that HSDB 3140 does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of HSDB 3140 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About HSDB 3140 usage in lactation

Short-acting benzodiacepine. Diazepam active metabolite. Excreted into breast milk in non-significant level. No harm effects on breastfed infants have been shown. Eventual and low dose use of benzodiacepines are compatible with breastfeeding. Use the short-acting benzodiazepine and minimal effective dose as possible mostly in the neonatal period. Check-up for infant sedation and feeding problems. Bed-sharing is not recommended for mothers who are taking this medication.

Answer by DrLact: About HSDB 3140 usage in lactation

HSDB 3140 has low levels in breastmilk, a short half-life relative to many other benzodiazepines, and is administration directly to infants. HSDB 3140 would not be expected to cause any adverse effects in breastfed infants with usual maternal dosages. No special precautions are required.

HSDB 3140 Side Effects in Breastfeeding

A woman with major depression was treated with HSDB 3140 and her breastfed infant was reportedly sedated. The dosage of HSDB 3140, age of the infant and extent of nursing were not reported.[4] In a telephone follow-up study, 124 mothers who took a benzodiazepine while nursing reported whether their infants had any signs of sedation. Two mothers took HSDB 3140 while breastfeeding and neither reported sedation in her infant.[5]