Is Ro 5-6789 Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use Ro 5-6789? Is Ro 5-6789 safe for nursing mother and child? Does Ro 5-6789 extracts into breast milk? Does Ro 5-6789 has any long term or short term side effects on infants? Can Ro 5-6789 influence milk supply or can Ro 5-6789 decrease milk supply in lactating mothers?

Ro 5-6789 lactation summary

DrLact safety Score for Ro 5-6789 is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of Ro 5-6789 is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that Ro 5-6789 does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of Ro 5-6789 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Ro 5-6789 usage in lactation

Short-acting benzodiacepine. Diazepam active metabolite. Excreted into breast milk in non-significant level. No harm effects on breastfed infants have been shown. Eventual and low dose use of benzodiacepines are compatible with breastfeeding. Use the short-acting benzodiazepine and minimal effective dose as possible mostly in the neonatal period. Check-up for infant sedation and feeding problems. Bed-sharing is not recommended for mothers who are taking this medication.

Answer by DrLact: About Ro 5-6789 usage in lactation

Ro 5-6789 has low levels in breastmilk, a short half-life relative to many other benzodiazepines, and is administration directly to infants. Ro 5-6789 would not be expected to cause any adverse effects in breastfed infants with usual maternal dosages. No special precautions are required.

Ro 5-6789 Side Effects in Breastfeeding

A woman with major depression was treated with Ro 5-6789 and her breastfed infant was reportedly sedated. The dosage of Ro 5-6789, age of the infant and extent of nursing were not reported.[4] In a telephone follow-up study, 124 mothers who took a benzodiazepine while nursing reported whether their infants had any signs of sedation. Two mothers took Ro 5-6789 while breastfeeding and neither reported sedation in her infant.[5]