Is Protamine Sulphate Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Protamine Sulphate? Is Protamine Sulphate safe for nursing mother and child? Does Protamine Sulphate extracts into breast milk? Does Protamine Sulphate has any long term or short term side effects on infants? Can Protamine Sulphate influence milk supply or can Protamine Sulphate decrease milk supply in lactating mothers?
Protamine Sulphate lactation summary
- DrLact safety Score for Protamine Sulphate is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Protamine Sulphate may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Protamine Sulphate may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Protamine Sulphate low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Protamine Sulphate We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Protamine Sulphate usage in lactation
Sperm protein of salmonide fish that may be used as heparin antidote (neutralizing effect by forming non-active stable complexes), and, as a drug to delay absorption of Insulin (NPH Insulin). Due to its protein structure a trespass to breast milk, or, oral absorption is highly unlikely.
Alternate Drugs for Antidotes, chelating (Fe) & detoxifying (Onco) agents & other therapeutic products. ATC V03
Naloxone(Low Risk)
Deferoxamine(Low Risk)
Sugammadex(Safe)
Acetylcysteine(Safe)
Dimercaprol(Low Risk)
Flumazenil(Low Risk)
Ipecacuanha(Safe)
Methyltionine Chloride(Low Risk)
Dl-Methioninum(Low Risk)
Amyl Nitrite(Low Risk)
Succimer(Low Risk)
Sugammadex Sodium(Safe)
Dmsa(Low Risk)
Bal(Low Risk)
Flumazepil(Low Risk)
Racemethionine(Low Risk)