Is 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide? Is 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide safe for nursing mother and child? Does 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide extracts into breast milk? Does 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide has any long term or short term side effects on infants? Can 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide influence milk supply or can 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide decrease milk supply in lactating mothers?
3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide lactation summary
- DrLact safety Score for 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide usage in lactation
Until more information on other Triptan-related compounds are available 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide is thought to be the safest one because of both a low excretion into breast milk and a low gut absorption.
Answer by DrLact: About 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide usage in lactation
BBecause of the low levels of 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide in breastmilk, amounts ingested by the infant are small. It also has poor oral bioavailability, further decreasing infant exposure to the drug. Some authors have suggested that withholding breastfeeding for 8 hours after a single subcutaneous injection would virtually eliminate infant exposure to the drug.[1] The manufacturer recommends withholding breastfeeding for 12 hours after a dose. Withholding breastfeeding might be helpful in extreme cases, such as in the mother of a preterm infant, but 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide would not be expected to cause any adverse effects in most breastfed infants. One anecdotal report of lactation ceasing after a single injection of 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide has not been verified.
3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide Side Effects in Breastfeeding
One author reported correspondence with the drug's manufacturer stating that of 3 women known to the manufacturer who used 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide (dose and route unspecified) during breastfeeding none reported adverse effects on the infants.[2]
3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide Possible Effects in Breastfeeding
One author reported correspondence with the drug's manufacturer stating that 1 woman who used a single injection of 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide (dose unspecified) during breastfeeding had a cessation of lactation.[2]
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