Is GR 43175X Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use GR 43175X? Is GR 43175X safe for nursing mother and child? Does GR 43175X extracts into breast milk? Does GR 43175X has any long term or short term side effects on infants? Can GR 43175X influence milk supply or can GR 43175X decrease milk supply in lactating mothers?
GR 43175X lactation summary
- DrLact safety Score for GR 43175X is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of GR 43175X is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that GR 43175X does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of GR 43175X safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About GR 43175X usage in lactation
Until more information on other Triptan-related compounds are available GR 43175X is thought to be the safest one because of both a low excretion into breast milk and a low gut absorption.
Answer by DrLact: About GR 43175X usage in lactation
BBecause of the low levels of GR 43175X in breastmilk, amounts ingested by the infant are small. It also has poor oral bioavailability, further decreasing infant exposure to the drug. Some authors have suggested that withholding breastfeeding for 8 hours after a single subcutaneous injection would virtually eliminate infant exposure to the drug.[1] The manufacturer recommends withholding breastfeeding for 12 hours after a dose. Withholding breastfeeding might be helpful in extreme cases, such as in the mother of a preterm infant, but GR 43175X would not be expected to cause any adverse effects in most breastfed infants. One anecdotal report of lactation ceasing after a single injection of GR 43175X has not been verified.
GR 43175X Side Effects in Breastfeeding
One author reported correspondence with the drug's manufacturer stating that of 3 women known to the manufacturer who used GR 43175X (dose and route unspecified) during breastfeeding none reported adverse effects on the infants.[2]
GR 43175X Possible Effects in Breastfeeding
One author reported correspondence with the drug's manufacturer stating that 1 woman who used a single injection of GR 43175X (dose unspecified) during breastfeeding had a cessation of lactation.[2]
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