Is AVP-825 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use AVP-825? Is AVP-825 safe for nursing mother and child? Does AVP-825 extracts into breast milk? Does AVP-825 has any long term or short term side effects on infants? Can AVP-825 influence milk supply or can AVP-825 decrease milk supply in lactating mothers?
AVP-825 lactation summary
- DrLact safety Score for AVP-825 is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of AVP-825 is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that AVP-825 does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of AVP-825 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About AVP-825 usage in lactation
Until more information on other Triptan-related compounds are available AVP-825 is thought to be the safest one because of both a low excretion into breast milk and a low gut absorption.
Answer by DrLact: About AVP-825 usage in lactation
BBecause of the low levels of AVP-825 in breastmilk, amounts ingested by the infant are small. It also has poor oral bioavailability, further decreasing infant exposure to the drug. Some authors have suggested that withholding breastfeeding for 8 hours after a single subcutaneous injection would virtually eliminate infant exposure to the drug.[1] The manufacturer recommends withholding breastfeeding for 12 hours after a dose. Withholding breastfeeding might be helpful in extreme cases, such as in the mother of a preterm infant, but AVP-825 would not be expected to cause any adverse effects in most breastfed infants. One anecdotal report of lactation ceasing after a single injection of AVP-825 has not been verified.
AVP-825 Side Effects in Breastfeeding
One author reported correspondence with the drug's manufacturer stating that of 3 women known to the manufacturer who used AVP-825 (dose and route unspecified) during breastfeeding none reported adverse effects on the infants.[2]
AVP-825 Possible Effects in Breastfeeding
One author reported correspondence with the drug's manufacturer stating that 1 woman who used a single injection of AVP-825 (dose unspecified) during breastfeeding had a cessation of lactation.[2]
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