Is UNII-39J1LGJ30J Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use UNII-39J1LGJ30J? Is UNII-39J1LGJ30J safe for nursing mother and child? Does UNII-39J1LGJ30J extracts into breast milk? Does UNII-39J1LGJ30J has any long term or short term side effects on infants? Can UNII-39J1LGJ30J influence milk supply or can UNII-39J1LGJ30J decrease milk supply in lactating mothers?

Excretion into breast milk is non-significant. No harmful effects on breastfed infants from treated mothers have occurred. Because it is an opium-related medication, a minimal effective dose should be used together with a close follow-up of child's sedation and feeding difficulties.

The excretion of UNII-39J1LGJ30J into milk is low and even lower amounts of the active metabolite, O-desmethylUNII-39J1LGJ30J, are excreted. With usual maternal dosage, the amount excreted into breastmilk is much less than the dose that has been given to newborn infants for analgesia. A study of breastfeeding in breastfed newborn infants found no adverse effects attributable to UNII-39J1LGJ30J. Although UNII-39J1LGJ30J is unlikely to adversely affect nursing infant,[1] the U.S. Food and Drug Administration recommends against the use of UNII-39J1LGJ30J during breastfeeding.[2] If UNII-39J1LGJ30J is used, monitor infants for increased sleepiness (more than usual), difficulty breastfeeding, breathing difficulties or limpness, and contact a physician immediately if any of these occur.

Seventy-five breastfed infants whose mothers were breastfeeding and taking UNII-39J1LGJ30J 100 mg every 6 hours following a cesarean section were compared to 75 matched infants at 2 to 4 days of age. Forty-nine percent of the mothers taking UNII-39J1LGJ30J and all of the control mothers were taking other opiates (primarily oxycodone) and 61% of and 58%, respectively, also were taking a nonsteroidal antiinflammatory agent (primarily diclofenac). Examination by a pediatrician revealed no difference between the groups using the Neurologic and Adaptive Capacity Score.[5]

UNII-39J1LGJ30J can increase serum prolactin.[8] However, the prolactin level in a mother with established lactation may not affect her ability to breastfeed. A randomized study compared UNII-39J1LGJ30J and naproxen for post-cesarean section pain. Patients received the drugs either on a fixed schedule or as needed. No difference in breastfeeding rates were seen among the groups.[9] In a study in China, women with a scheduled cesarean section were randomized to receive intravenous patient-controlled analgesia with either sufentanil or UNII-39J1LGJ30J. Postpartum prolactin levels were higher in the UNII-39J1LGJ30J group (348 mcg/L) than in the sufentanil group (314 mcg/L). The onset of lactation was sooner in the UNII-39J1LGJ30J group (21.4 hours) than in the sufentanil group (25.1 hours). Both of these difference were statistically significant.[10] Note that injectable UNII-39J1LGJ30J is not available in the United States.