Question

I am a breastfeeding mother and i want to know if it is safe to use HSDB 8158? Is HSDB 8158 safe for nursing mother and child? Does HSDB 8158 extracts into breast milk? Does HSDB 8158 has any long term or short term side effects on infants? Can HSDB 8158 influence milk supply or can HSDB 8158 decrease milk supply in lactating mothers?

HSDB 8158 lactation summary

HSDB 8158 is safe in breastfeeding
  • DrLact safety Score for HSDB 8158 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of HSDB 8158 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that HSDB 8158 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of HSDB 8158 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About HSDB 8158 usage in lactation

S-Enantiomer of Omeprazole with which shares similar characteristics. Due to a high serum-protein-binding capacity, Omeprazole is excreted into breast milk in non-significant amount without side-effects among breastfed infants from treated mothers. Since it's neutralized by the acid pH of stomach, capsules with enteric coated granules are used. Because of this, it is thought that the small quantity of Omeprazole that may reach the breast milk would be neutralized by infant's stomach. In addition, absorption is greatly decreased by the presence of food. HSDB 8158 has been used for treatment of newborn and premature infants. Hyperprolactinemia and galactorrhea have been reported by the use of Omeprazole.

Answer by DrLact: About HSDB 8158 usage in lactation

HSDB 8158 is the -enantiomer of the proton-pump inhibitor, omeprazole. Limited information indicates that maternal doses of 20 mg daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants.

HSDB 8158 Side Effects in Breastfeeding

One mother taking omeprazole 20 mg daily orally pumped and discarded her milk once each day 4 hours after her morning dose. She breastfed her infant the remainder of the day for 3 months before weaning. The infant remained well at 12 months of age.[1]

HSDB 8158 Possible Effects in Breastfeeding

Omeprazole has been reported to cause gynecomastia in men.[2] One woman developed elevated serum prolactin and estradiol with bilateral galactorrhea one week after starting HSDB 8158 40 mg once daily for reflux esophagitis. The galactorrhea disappeared 3 days after discontinuing HSDB 8158 and prolactin and estradiol returned to normal 7 days after discontinuation. One month later, the patient restarted HSDB 8158 and again developed bilateral galactorrhea. She was switched to lansoprazole with no galactorrhea developing.[3] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.