Question

I am a breastfeeding mother and i want to know if it is safe to use SK&F 8542? Is SK&F 8542 safe for nursing mother and child? Does SK&F 8542 extracts into breast milk? Does SK&F 8542 has any long term or short term side effects on infants? Can SK&F 8542 influence milk supply or can SK&F 8542 decrease milk supply in lactating mothers?

SK&F 8542 lactation summary

SK&F 8542 usage has low risk in breastfeeding
  • DrLact safety Score for SK&F 8542 is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of SK&F 8542 may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that SK&F 8542 may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of SK&F 8542 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using SK&F 8542 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About SK&F 8542 usage in lactation

Long-term treatment with diuretic drugs (particularly those Thiazides with long lasting effect and loop-acting drugs) may inhibit lactation. Use a lower dose as possible, especially during the first postnatal month.I has been marketed in association to Furosemide in Spain.

Answer by DrLact: About SK&F 8542 usage in lactation

If SK&F 8542 is required by the mother, it is not a reason to discontinue breastfeeding. However, because no information is available on the use of SK&F 8542 during breastfeeding, an alternate drug may be preferred.

SK&F 8542 Possible Effects in Breastfeeding

Intense diuresis can suppress lactation;[1][2] however, it is unlikely that SK&F 8542 alone is sufficiently potent to cause this effect.

Alternate Drugs

Amiloride(Low Risk)
Methazolamide
Acetazolamide(Safe)
Triamterene(Low Risk)
Spironolactone(Safe)

Synonyms of SK&F 8542

5-26-17-00447 (Beilstein Handbook Reference)
Ademin
Ademin(e)
Ademine
AI3-60017
BRN 0266723
CCRIS 5872
Diren
Ditak
Diurene
Dyren
Dyrenium
Dytac
EINECS 206-904-3
HSDB 3405
Jatropur
NCI C56042
Noridil
Noridyl
NSC 77625
6-Phenyl-2,4,7-pteridinetriamine
6-Phenyl-2,4,7-triaminopteridine
Pteridine, 2,4,7-triamino-6-phenyl-
2,4,7-Pteridinetriamine, 6-phenyl-
Pterofen
Pterophene
SKF 8542
Taturil
Teriam
Teridin
2,4,7-Triamino-6-fenilpteridina [Italian]
2,4,7-Triamino-6-phenylpteridine
Triampur
Triamteren
Triamterena [INN-Spanish]
Triamterenum [INN-Latin]
Triamteril
Triamteril complex
Tri-Span
Triteren
Urocaudal
Amteren
Anjal
Apo-triazide
Dazid
Diarol
Dinazide
Diucelpin
Diutensat
Diuteren
Dyberzide
Dytenzide
Esiteren
Fluss 40
Hidiurese
Hydrene
Hypertorr
Isobar
Jenateren
Kalspare
Masuharmin
Nephral
Renezide
Reviten
SALI-PUREN
Thiazid Wolff
Triamizide
Triamthiazid
Triazide
Tricilone
Trispan
Triurene
Trizid
Turfa
Uretren
NSC 639359
2,4,7-Triamino-6-fenilpteridina
Triamterena
Triamterenum
UNII-WS821Z52LQ
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.