Question

I am a breastfeeding mother and i want to know if it is safe to use Meropenem? Is Meropenem safe for nursing mother and child? Does Meropenem extracts into breast milk? Does Meropenem has any long term or short term side effects on infants? Can Meropenem influence milk supply or can Meropenem decrease milk supply in lactating mothers?

Meropenem lactation summary

Meropenem is safe in breastfeeding
  • DrLact safety Score for Meropenem is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Meropenem is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Meropenem does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Meropenem safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Meropenem usage in lactation

Antibacterial carbapenem beta-lactam with indications similar to imipenem.Intravenous administration every 8 hours. It is excreted in breast milk in a clinically insignificant amount (Sauberan 2012) and no problems have been observed in infants whose mothers took it (Festini 2004). Authorized pediatric use in infants and newborns. It is considered by experts to be compatible with breastfeeding (Rowe 2013). The possible negativity of cultures in febrile infants whose mothers take antibiotics should be taken into account, as well as the possibility of gastroenteritis due to altered intestinal flora (Benyamini 2005, Ito 1993, Kafetzis 1981).

Answer by DrLact: About Meropenem usage in lactation

Although no information is available on the use of meropenem during breastfeeding, milk levels appear to be low and beta-lactams are generally not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with beta-lactams, but these effects have not been adequately evaluated. Vaborbactam, which is available in the combination product Vabomere, has not been studied in nursing mothers, but the combination is expected to have similar concerns as with meropenem alone.

Meropenem Side Effects in Breastfeeding

A mother received meropenem 1 gram IV every 8 hours for 7 days while exclusively breastfeeding her newborn. When questioned later, she stated that her infant had no oral thrush, watery diarrhea, or diaper dermatitis that required antifungal therapy during the month following her meropenem therapy.[1] An infant was breastfed (extent not stated) until the 4th month postpartum. At 2 months of age, his mother was given a 2-week course of tobramycin and meropenem (dosage not specified) for a cystic fibrosis exacerbation. The infant displayed no change in stool pattern during the maternal treatment and had normal renal function at 6 months of age.[2]

Alternate Drugs

Ofloxacin(Safe)
Cefoxitin(Safe)
Gatifloxacin(Low Risk)
Amantadine(Low Risk)
Tenofovir(Safe)
Cefotetan(Safe)
Efavirenz(Unsafe)
Enoxacin(Low Risk)
Neomycin(Safe)
Didanosine(Unsafe)
Doxycycline(Low Risk)
Nafcillin(Safe)
Amikacin(Safe)
Saquinavir(Unsafe)
Moxifloxacin(Low Risk)
Naftifine(Safe)
Demeclocycline(Low Risk)
Cefixime(Safe)
Ritonavir(Unsafe)
Methicillin(Low Risk)
Cefepime(Safe)
Primaquine(Low Risk)
Abacavir(Safe)
Famciclovir(Low Risk)
Atovaquone(Low Risk)
Malathion(Low Risk)
Erythromycin(Low Risk)
Nevirapine(Low Risk)
Meropenem(Safe)
Cefdinir(Safe)
Linezolid(Low Risk)
Clindamycin(Low Risk)
Nelfinavir(Unsafe)
Valganciclovir(Low Risk)
Lindane(Unsafe)
Cefazolin(Safe)
Lomefloxacin(Low Risk)
Ganciclovir(Low Risk)
Levofloxacin(Low Risk)
Cefaclor(Safe)
Dapsone(Low Risk)
Econazole(Safe)
Acyclovir(Safe)
Kanamycin(Safe)
Capreomycin(Low Risk)
Quinine(Safe)
Indinavir(Unsafe)
Rifaximin(Safe)
Ertapenem(Safe)
Cefprozil(Safe)
Aztreonam(Safe)
Zidovudine(Low Risk)
Meropenem(Safe)
Ertapenem(Safe)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.