Is 2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)-methyl)- Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use 2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)-methyl)-? Is 2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)-methyl)- safe for nursing mother and child? Does 2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)-methyl)- extracts into breast milk? Does 2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)-methyl)- has any long term or short term side effects on infants? Can 2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)-methyl)- influence milk supply or can 2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)-methyl)- decrease milk supply in lactating mothers?

It is excreted in breast milk in clinically non-significant amount. No problems have been observed in infants whose mothers were treated. Medication which is used in infants from the second month of age. Take into account the possibility of negative false results of cultures from febrile infants whose mothers are taking antibiotics as well as the possibility of acute diarrhea due to imbalance of the intestinal flora. The American Academy of Pediatric states that it is usually compatible with breastfeeding medication.WHO List of Essential Medicines from 2002 has classified it as compatible with breastfeeding.

Because of the low levels of 2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)-methyl)- in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.

In one study, no adverse effects were noted in infants during 4 days of maternal therapy with co-trimoxazole.[1] In a telephone follow-up study, 12 nursing mothers reported taking co-trimoxazole (dosage unspecified). Two mothers reported poor feeding in their infants. Diarrhea was not reported among the exposed infants.[4]