Is Mepyramine Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Mepyramine? Is Mepyramine safe for nursing mother and child? Does Mepyramine extracts into breast milk? Does Mepyramine has any long term or short term side effects on infants? Can Mepyramine influence milk supply or can Mepyramine decrease milk supply in lactating mothers?

First generation antihistamine with sedative and important antimuscarinic effects. Such remarkable anticholinergic effect may inhibit lactation. At latest update no published data on excretion into breast milk were found. Drug with poor scientific support which is marketed in very few countries.Marketed as part of in many “at the counter” compounds in association poliasociación with expectorants, bronchodilators, antitussives, etc. Avoid the use of drug associations mostly while breastfeeding. Although occasional and moderate use during lactation would probably not pose a serious risk, a safer alternative should be preferred until more data on this drug related to breastfeeding is available. Topically used on the skin, it would not represent a risk during breastfeeding. Avoid applying it on the breast. Assess the child for drowsiness and inappropriate infant feeding.It is not recommended bed-sharing with your baby if you are on this medication.

Small, occasional doses of pyrilamine are probably acceptable during breast feeding. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly, in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

Relevant published information on pyrilamine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to pyrilamine.[2]

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.