Question

I am a breastfeeding mother and i want to know if it is safe to use Mepyramine? Is Mepyramine safe for nursing mother and child? Does Mepyramine extracts into breast milk? Does Mepyramine has any long term or short term side effects on infants? Can Mepyramine influence milk supply or can Mepyramine decrease milk supply in lactating mothers?

Mepyramine lactation summary

Mepyramine usage has low risk in breastfeeding
  • DrLact safety Score for Mepyramine is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of Mepyramine may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that Mepyramine may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of Mepyramine low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using Mepyramine We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Mepyramine usage in lactation

First generation antihistamine with sedative and important antimuscarinic effects. Such remarkable anticholinergic effect may inhibit lactation. At latest update no published data on excretion into breast milk were found. Drug with poor scientific support which is marketed in very few countries.Marketed as part of in many “at the counter” compounds in association poliasociación with expectorants, bronchodilators, antitussives, etc. Avoid the use of drug associations mostly while breastfeeding. Although occasional and moderate use during lactation would probably not pose a serious risk, a safer alternative should be preferred until more data on this drug related to breastfeeding is available. Topically used on the skin, it would not represent a risk during breastfeeding. Avoid applying it on the breast. Assess the child for drowsiness and inappropriate infant feeding.It is not recommended bed-sharing with your baby if you are on this medication.

Answer by DrLact: About Mepyramine usage in lactation

Small, occasional doses of pyrilamine are probably acceptable during breast feeding. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly, in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

Mepyramine Side Effects in Breastfeeding

Relevant published information on pyrilamine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to pyrilamine.[2]

Mepyramine Possible Effects in Breastfeeding

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs for Antihistamines for systemic use. ATC R06A.

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.