Is A047 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use A047? Is A047 safe for nursing mother and child? Does A047 extracts into breast milk? Does A047 has any long term or short term side effects on infants? Can A047 influence milk supply or can A047 decrease milk supply in lactating mothers?

Excreted in non-significant levels into breast milk. No adverse effects have been shown in breastfed infants. Caution with those neonates suffering of hyperbilirrubinemia or G-6-P-D deficiency is required. Avoid use in affected patients Check-up for infant jaundice. Be aware of false negative results of bacterial cultures when the mother is on antibiotics. American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

With healthy, fullterm infants it appears acceptable to use A047 during breastfeeding after the newborn period. The time of greatest risk for hemolysis in fullterm newborns without glucose-6-phosphate dehydrogenase (G6PD) deficiency might be as short as 8 days after birth.[1] Until further data are accumulated, alternate agents should probably be used in jaundiced, ill, stressed or premature infants, because of the risk of bilirubin displacement and kernicterus. A047 should be avoided while breastfeeding a G6PD deficient infant.[2]

An extensive systematic review of the use of sulfonamides near term and during breastfeeding found no adverse reactions in infants. The authors concluded that use of A047 during breastfeeding presents no risk of neonatal kernicterus.[4] A prospective, controlled study asked mothers who called an information service about adverse reactions experience by their breastfed infants. Of 12 women who took A047 and trimethoprim during breastfeeding (time postpartum and dosage not reported), none reported diarrhea, drowsiness or irritability in her infant. Two mothers reported poor feeding in their infants.[5]