Is Pancuronium Bromide Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Pancuronium Bromide? Is Pancuronium Bromide safe for nursing mother and child? Does Pancuronium Bromide extracts into breast milk? Does Pancuronium Bromide has any long term or short term side effects on infants? Can Pancuronium Bromide influence milk supply or can Pancuronium Bromide decrease milk supply in lactating mothers?
Pancuronium Bromide lactation summary
- DrLact safety Score for Pancuronium Bromide is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Pancuronium Bromide may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Pancuronium Bromide may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Pancuronium Bromide low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Pancuronium Bromide We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Pancuronium Bromide usage in lactation
It is a non-depolarizing muscle relaxant drug with a peripheral action that is used as premedication for endotracheal intubation, general anesthesia and mechanical ventilation. At latest update, no relevant published data concerning excretion into breast milk were found. Because a relatively high molecular-weight and a high protein-binding capacity, excretion into breast milk is thought to be low. It has a low oral bioavailability which means that absorption from the breast milk ingested may be low. Pancuronium should not prevent a mother from breast feeding her baby shortly after recovering from an anesthesia if she is in good condition. However, other muscle relaxants with a more rapid elimination time period and better known drugs are preferred.
Answer by DrLact: About Pancuronium Bromide usage in lactation
No information is available on the use of pancuronium during breastfeeding. Because it is highly polar and poorly absorbed orally, it is not likely to reach the breastmilk in high concentration or to reach the bloodstream of the infant.[1][2] When a combination of anesthetic agents is used for a procedure, follow the recommendations for the most problematic medication used during the procedure.
Alternate Drugs for Muscle relaxants. ATC M03
Baclofen(Safe)
Carisoprodol(Low Risk)
Dantrolene(Unsafe)
Cyclobenzaprine(Low Risk)
Pancuronium(Low Risk)
Atracurium(Safe)
Rocuronium(Safe)
Alcuronium Chloride(Low Risk)
Mivacurium(Safe)
Methocarbamol(Low Risk)
Mephenesine(Unsafe)
Metaxalone(Unsafe)
Suxamethonium Chloride(Safe)
Thiocolchicoside(Unsafe)
Tizanidine Hydrochloride(Unsafe)
Tubocurarine(Low Risk)
Vecuronium Bromide(Low Risk)
Pridinol Mesilate(Unsafe)
Chlorzoxazone(Unsafe)
Rocuronium Bromide(Safe)
Diallylnortoxiferine Dichloride(Low Risk)
Succinylcholine(Safe)
Mivacurium Chloride(Safe)