Is Cotrim Holsen Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Cotrim Holsen? Is Cotrim Holsen safe for nursing mother and child? Does Cotrim Holsen extracts into breast milk? Does Cotrim Holsen has any long term or short term side effects on infants? Can Cotrim Holsen influence milk supply or can Cotrim Holsen decrease milk supply in lactating mothers?

Mixture of 5 parts of Sulfamethoxazole and 1 part of Trimethoprim. See info on items separately. Trimethoprim is excreted into breast milk at 4 to 10% of corrected pediatric dose. No adverse effects have been shown in breastfed infants. Used for treatment of infants older than one month. Sulfamethoxazole is excreted in low levels into breast milk.No adverse effects have been shown in breastfed infants. Cautious use for treatment of premature infants with hyperbilirubinemia or G-6-P-D deficiency is required. Avoid use in affected patients . Check-up for infant jaundice. Be aware of false negative results of bacterial cultures when the mother is on antibiotics and diarrheal disease due to intestinal flora imbalance. The American Academy of Pediatrics rates it compatible with breastfeeding. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding for older, healthy full- term infants. See below the information of these related products:

With healthy, fullterm infants it appears acceptable to use sulfamethoxazole and trimethoprim during breastfeeding after the newborn period. The time of greatest risk for hemolysis in fullterm newborns without glucose-6-phosphate dehydrogenase (G6PD) deficiency might be as short as 8 days after birth.[1] Until further data are accumulated, alternate agents should probably be used in jaundiced, ill, stressed or premature infants, because of the risk of bilirubin displacement and kernicterus. Sulfamethoxazole and trimethoprim should be avoided while breastfeeding a G6PD-deficient infant.[2][3]

An extensive systematic review of the use of sulfonamides near term and during breastfeeding found no adverse reactions in infants. The authors concluded that use of sulfamethoxazole-trimethoprim during breastfeeding presents no risk of neonatal kernicterus.[7] A prospective, controlled study asked mothers who called an information service about adverse reactions experience by their breastfed infants. Of 12 women who took sulfamethoxazole and trimethoprim during breastfeeding (time postpartum and dosage not stated), none reported diarrhea, drowsiness or irritability in her infant. Two mothers reported poor feeding in their infants.[8]