Is Chlorambucil Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Chlorambucil? Is Chlorambucil safe for nursing mother and child? Does Chlorambucil extracts into breast milk? Does Chlorambucil has any long term or short term side effects on infants? Can Chlorambucil influence milk supply or can Chlorambucil decrease milk supply in lactating mothers?
Chlorambucil lactation summary
- DrLact safety Score for Chlorambucil is 7 out of 8 which is considered Dangerous as per our analyses.
- A safety Score of 7 indicates that usage of Chlorambucil may cause toxic or severe side effects in breastfed baby.
- Our study of different scientific research indicates that Chlorambucil may cause moderate to high side effects or may affect milk supply in lactating mother.
- Our suggestion is to use safer alternate options rather than using Chlorambucil .
- Usage of Chlorambucil is in contradiction to breastfeeding hence if it is must to use Chlorambucil and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Chlorambucil usage in lactation
Drug is cleared from the body in 12 elimination half-lives. Resuming breastfeeding is likely safe after 24 hours of pumping-and-dumping.
Alternate Drugs for Antineoplastic agents. ATC L01
Busulfan(Dangerous)
Cisplatin(Unsafe)
Cyclophosphamide(Dangerous)
Doxorubicin(Dangerous)
Etoposide(Dangerous)
Hydroxyurea(Low Risk)
Mercaptopurine(Safe)
Mitoxantrone(Dangerous)
Vincristine(Dangerous)
Methotrexate(Low Risk)
Imatinib(Unsafe)
Trastuzumab(Unsafe)
Bevacizumab(Low Risk)
Rituximab(Low Risk)
Alemtuzumab(Low Risk)
Fluorouracil(Dangerous)
Paclitaxel(Dangerous)
Carboplatin(Dangerous)
Cetuximab(Unsafe)
Brentuximab Vedotin(Low Risk)
Ipilimumab(Unsafe)
Everolimus(Unsafe)
Thioguanine(Dangerous)
Dacarbazine(Dangerous)
Vinorelbine(Dangerous)
Bleomycin(Dangerous)
Vinblastine(Dangerous)
Nivolumab(Unsafe)
Nilotinib(Unsafe)
Dasatinib(Unsafe)
Cladribine(Dangerous)
Erlotinib(Unsafe)
Pazopanib(Unsafe)
Capecitabine(Dangerous)
Docetaxel(Dangerous)
Carmustine(Dangerous)
Exemestane(Dangerous)
Gemcitabine(Dangerous)
Dactinomycin(Dangerous)
Epirubucin(Dangerous)
Fluorouracil Topical Solution(Low Risk)
Idarubicin-Hcl(Dangerous)
Ifosfamide(Dangerous)
Melphalan(Dangerous)
Mitomycin(Dangerous)
Oxaliplatin(Dangerous)
Pentostatin(Dangerous)
Procarbazine(Dangerous)
Teniposide(Dangerous)
Thiotepa(Dangerous)
Tretinoin Oral(Dangerous)
Vinorelbine Tartrate(Dangerous)
Imatinib Mesilate(Unsafe)
Altretamine(Dangerous)
Aminoglutethimide(Dangerous)
5-Aminolevulinic Acid(Low Risk)
Hydroxycarbamide(Low Risk)
Anastrozole(Dangerous)
Arsenic-Trioxide(Dangerous)
Asparaginase(Dangerous)
Bexarotene(Dangerous)
Cytarabine(Dangerous)
Chlormethine(Dangerous)
Daunorubicin(Dangerous)
Rubidomycin(Dangerous)
Amethopterin(Low Risk)
Vincaleukoblastine(Dangerous)
Doxorubicin Hydrochloride(Dangerous)
Vlb(Dangerous)
Mechlorethamine(Dangerous)
Platinum Diamminodichloride(Unsafe)
4-Amino-10-methylfolic Acid(Low Risk)
5-ALA(Low Risk)
5-Fu(Dangerous)
6-Mercaptopurine(Safe)
6-Thiohypoxanthine(Safe)
6-Thioxopurine(Safe)
MTX(Low Risk)
Cytosine Arabinoside(Dangerous)
Daunomycin(Dangerous)
Actinomycin D(Dangerous)
Deoxycoformycin(Dangerous)