Question

I am a breastfeeding mother and i want to know if it is safe to use Knockout drops? Is Knockout drops safe for nursing mother and child? Does Knockout drops extracts into breast milk? Does Knockout drops has any long term or short term side effects on infants? Can Knockout drops influence milk supply or can Knockout drops decrease milk supply in lactating mothers?

Knockout drops lactation summary

Knockout drops usage has low risk in breastfeeding
  • DrLact safety Score for Knockout drops is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of Knockout drops may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that Knockout drops may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of Knockout drops low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using Knockout drops We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Knockout drops usage in lactation

Sporadic use is harmless. (Used as a hypnotic drug for non painful procedures: CAT, EEG, MRI, etc. A repetitive use may be a cause of somnolence. Not commercially available in Spain as a sedative or hypnotic drug. American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.

Answer by DrLact: About Knockout drops usage in lactation

Short-term or occasional use of Knockout drops during breastfeeding is unlikely to adversely affect the breastfed infant, especially if the infant is older than 2 months. Because the active metabolite of Knockout drops has a long half-life, other sedative-hypnotics are preferred for long-term use during breastfeeding, especially while nursing a neonate or preterm infant. Monitor the infant for excessive drowsiness.

Knockout drops Side Effects in Breastfeeding

An old review article states that if an infant is breastfed within 45 minutes of a maternal dose of Knockout drops while she is taking 1.5 grams twice daily, the infant will fall into a prolonged, restless sleep.[3] A single maternal rectal dose of 1.3 grams Knockout drops in 50 women was stated to not adversely affect their breastfed newborn infants.[1] Minimal morning sedation occurred in a 5-month-old breastfed infant whose mother was taking 1.3 grams of dichloralphenazone (equivalent to about 1 gram of Knockout drops) every evening plus chlorpromazine 100 mg 3 times daily. The infant's overall development was said to be normal at 3 months of age.[2]

Alternate Drugs

Sodium Oxybate(Low Risk)
Chloral Hydrate(Low Risk)
Nitrazepam(Low Risk)
Zolpidem(Safe)
Zaleplon(Safe)
Triazolam(Low Risk)
Ketamine(Low Risk)
Temazepam(Low Risk)
Estazolam(Low Risk)
Quazepam(Unsafe)
Flurazepam(Unsafe)
Phenobarbital(Low Risk)
Meprobamate(Low Risk)
Oxazepam(Safe)
Butalbital(Low Risk)
Midazolam(Safe)
Butabarbital(Low Risk)
Lorazepam(Safe)
Pentobarbital(Low Risk)
Eszopiclone(Low Risk)
Secobarbital(Low Risk)
Diazepam(Low Risk)
Clorazepate(Low Risk)
Propofol(Safe)
Alprazolam(Low Risk)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.