Is I-1431 Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use I-1431? Is I-1431 safe for nursing mother and child? Does I-1431 extracts into breast milk? Does I-1431 has any long term or short term side effects on infants? Can I-1431 influence milk supply or can I-1431 decrease milk supply in lactating mothers?

I-1431 lactation summary

DrLact safety Score for I-1431 is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of I-1431 is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that I-1431 does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of I-1431 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About I-1431 usage in lactation

American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.

Answer by DrLact: About I-1431 usage in lactation

Limited information from an old study indicates that maternal doses of I-1431 of 1 gram daily produce moderate levels in milk. If I-1431 is required by the mother, it is not a reason to discontinue breastfeeding, especially if the infant is older than 2 months. Exclusively breastfed infants should be monitored if this drug is used during lactation, possibly including measurement of serum levels to rule out toxicity if there is a concern.

I-1431 Side Effects in Breastfeeding

No adverse effects were noted in 5 in breastfed infants (ages not stated) whose mothers were taking oral I-1431 250 mg 4 times daily.[1] I-1431 was used as part of multi-drug regimens to treat 5 women with multidrug-resistant tuberculosis, 4 throughout pregnancy and postpartum and the other postpartum only. The infants were breastfed (extent and duration not stated). At age 1.25, 1.8, 3.9, 4.6 and 5.5 years, the children were developing normally except for a mild speech delay in one and hyperactivity in another.[4]