Question

I am a breastfeeding mother and i want to know if it is safe to use Olsalazinum [Latin]? Is Olsalazinum [Latin] safe for nursing mother and child? Does Olsalazinum [Latin] extracts into breast milk? Does Olsalazinum [Latin] has any long term or short term side effects on infants? Can Olsalazinum [Latin] influence milk supply or can Olsalazinum [Latin] decrease milk supply in lactating mothers?

Olsalazinum [Latin] lactation summary

Olsalazinum [Latin] is safe in breastfeeding
  • DrLact safety Score for Olsalazinum [Latin] is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Olsalazinum [Latin] is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Olsalazinum [Latin] does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Olsalazinum [Latin] safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Olsalazinum [Latin] usage in lactation

Prodrug of Mesalazine: Medication compounded by union of two molecules of 5-ASA resulting in a dimer which is degraded into monomeric Mesalazine (5-ASA) in the large intestine. Mesalazine is badly absorbed by the intestine, serum levels are low with scant excretion into breast milk. Traces of Olsalazinum [Latin] and/or Mesalazine have not been found in breast milk of treated mothers with Olsalazinum [Latin]. N-acetyl-5-ASA is an inactive metabolite which is excreted into breast milk but not higher than 1% of relative infant's dose. No harm effects among breastfed infants from treated mothers have been reported, except for rare cases of diarrhea reported in the 80's with the use of Mesalazine compounds different to Olsalazinum [Latin]. In a review of 121 cases and 121 controls, the authors failed to observe those findings. (Moretti, 1989). Expert consensus supports the compatibility of Mesalazine and/or its prodrugs during breastfeeding.

Answer by DrLact: About Olsalazinum [Latin] usage in lactation

Limited data indicate that Olsalazinum [Latin] is poorly excreted into breastmilk. However, Olsalazinum [Latin] is a mesalamine prodrug. Rather high levels of the mesalamine metabolite N-acetyl-5-ASA appear in breastmilk and its effects on breastfed infants are unknown. A few cases of diarrhea have been reported in infants exposed to mesalamine, although the rate is not high. Most experts consider mesalamine derivatives to be safe during breastfeeding.[1][2][3][4] If Olsalazinum [Latin] is required by the mother, it is not a reason to discontinue breastfeeding, but carefully observe breastfed infants for diarrhea during maternal use of Olsalazinum [Latin].

Olsalazinum [Latin] Side Effects in Breastfeeding

One infant was breastfed during maternal therapy with Olsalazinum [Latin] for Crohn's disease. After 2 and 3 weeks of therapy, no rash, wheezing, vomiting or diarrhea were noted in the infant.[5] The active metabolite of Olsalazinum [Latin], mesalamine, was probably responsible for diarrhea in a 6-week-old whose diarrhea recurred 4 times after rechallenge of the mother 4 times during breastfeeding.[7] Diarrhea has also been reported anecdotally by some nursing mothers,[8] but a small controlled study reported only in abstract form found no higher rate of diarrhea in the breastfed infants of mothers taking mesalamine than in control infants.[9]
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