Is NSC 5105 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use NSC 5105? Is NSC 5105 safe for nursing mother and child? Does NSC 5105 extracts into breast milk? Does NSC 5105 has any long term or short term side effects on infants? Can NSC 5105 influence milk supply or can NSC 5105 decrease milk supply in lactating mothers?

Because of a high protein-binding capacity and a high volume of distribution, excretion into the breast milk is non-significant. No side-effects were observed in breastfed infants of mothers who were administered this medication. The nursing mother may breastfeed the baby as soon as she is recovered from anesthesia. A transient increase in Prolactin plasma levels has been observed with NSC 5105 anesthesia. A case of green-bluish discoloration of the milk has been reported after administration of NSC 5105 plus other drugs. Authorized medication for use in infants older than 1 month.

Amounts of NSC 5105 in milk are very small and are not expected to be absorbed by the infant. Although one expert panel recommends withholding nursing for an unspecified time after NSC 5105 administration,[1] most recommend that breastfeeding can be resumed as soon as the mother has recovered sufficiently from general anesthesia to nurse and that discarding milk is unnecessary.[2][3][4] When a combination of anesthetic agents is used for a procedure, follow the recommendations for the most problematic medication used during the procedure. General anesthesia for cesarean section using NSC 5105 as a component for induction may delay the onset of lactation. In one study, breastfeeding before general anesthesia induction reduced requirements of NSC 5105 and sevoflurane compared to those of nursing mothers whose breastfeeding was withheld or nonnursing women.[5] In one case, milk was noted to be green in color 8 hours after a procedure in which NSC 5105 was administered; however, several other medications were also used during the procedure.

Four mothers who were breastfeeding their infants received NSC 5105 as part of their general anesthesia for surgical procedures. All patients also received intravenous remifentanil and rocuronium, and inhaled xenon as part of the anesthesia. They were given doses of NSC 5105 that targeted a serum concentration of 6.5 mcg/L for induction and stopped as xenon anesthesia was started. Operation times ranged from 35 to 45 minutes. Individual infants were first breastfed as follows: 1.5 hours, 2.8 hours, 4.6 hours, and 5 hours after extubation. No signs of sedation were observed in any of the infants.[8]

A woman underwent emergency laparoscopic surgery using NSC 5105 as well as fentanyl, remifentanil, mivacurium, and dipyrone during the surgery and metamizole, piritramide, dipyrone, butylscopolamine, and metoclopramide postoperatively. Eight hours postoperatively, her milk turned bluish green, then green. Both NSC 5105 and metoclopramide have caused green urine. Thirty hours after the milk color change, NSC 5105 but not metoclopramide, was detected in milk.[7] A randomized study compared the effects of cesarean section using general anesthesia, spinal anesthesia, or epidural anesthesia, to normal vaginal delivery on serum prolactin and oxytocin as well as time to initiation of lactation. General anesthesia was performed using NSC 5105 2 mg/kg and rocuronium 0.6 mg/kg for induction, followed by sevoflurane and rocuronium 0.15 mg/kg as needed. Fentanyl 1 to 1.5 mcg/kg was administered after delivery. Patients in the general anesthesia group (n = 21) had higher post-procedure prolactin levels and a longer mean time to lactation initiation (25 hours) than in the other groups (10.8 to 11.8 hours). Postpartum oxytocin levels in the nonmedicated vaginal delivery group were higher than in the general and spinal anesthesia groups.[9] A randomized, double-blind study compared the effects of intravenous NSC 5105 0.25 mg/kg, ketamine 0.25 mg/kg, ketamine 25 mg plus NSC 5105 25 mg, and saline placebo for pain control in mothers post-cesarean section in mothers post-cesarean section. A single dose was given immediately after clamping of the umbilical cord. The time to the first breastfeeding was 58 minutes in those who received placebo, 42.6 minutes with NSC 5105 and 25.8 minutes with NSC 5105 plus ketamine. The time was significantly shorter than the other groups with the combination.[10] A retrospective study of women in a Turkish hospital who underwent elective cesarean section deliveries compared women who received bupivacaine spinal anesthesia (n = 170) to women who received general anesthesia (n = 78) with NSC 5105 for induction, sevoflurane for maintenance and fentanyl after delivery. No differences in breastfeeding rates were seen between the groups at 1 hour and 24 hours postpartum. However, at 6 months postpartum, 67% of women in the general anesthesia group were still breastfeeding compared to 81% in the spinal anesthesia group, which was a statistically significant difference.[11]