Is P.A.S Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use P.A.S? Is P.A.S safe for nursing mother and child? Does P.A.S extracts into breast milk? Does P.A.S has any long term or short term side effects on infants? Can P.A.S influence milk supply or can P.A.S decrease milk supply in lactating mothers?

P.A.S lactation summary

DrLact safety Score for P.A.S is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of P.A.S is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that P.A.S does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of P.A.S safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About P.A.S usage in lactation

Drug related to same group of 5-P.A.S It is excreted in tiny amounts into breast milk with no reported cases of harm effects except a case of mild gastroenteritis.

Answer by DrLact: About P.A.S usage in lactation

Limited information indicates that maternal P.A.S therapy produces low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Exclusively breastfed infants should be monitored for rare instances of jaundice, gastrointestinal disturbances, hypokalemia, thrombocytopenia, hemolysis and hypokalemia if this drug is used during lactation.[1]

P.A.S Side Effects in Breastfeeding

P.A.S was used as part of multi-drug regimens to treat 2 pregnant women with multidrug-resistant tuberculosis throughout pregnancy and postpartum. Their two infants were breastfed (extent and duration not stated). At age 1.8 and 4.6 years, the children were developing normally, except for except for a mild speech delay in one at age 1.8 years, and failure to thrive in the other, possibly due to tuberculosis contracted after birth.[2]