Is 1,4-Bis(2-ethylhexyloxy)-1,4-dioxo-2-butansulfonsaeure Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use 1,4-Bis(2-ethylhexyloxy)-1,4-dioxo-2-butansulfonsaeure? Is 1,4-Bis(2-ethylhexyloxy)-1,4-dioxo-2-butansulfonsaeure safe for nursing mother and child? Does 1,4-Bis(2-ethylhexyloxy)-1,4-dioxo-2-butansulfonsaeure extracts into breast milk? Does 1,4-Bis(2-ethylhexyloxy)-1,4-dioxo-2-butansulfonsaeure has any long term or short term side effects on infants? Can 1,4-Bis(2-ethylhexyloxy)-1,4-dioxo-2-butansulfonsaeure influence milk supply or can 1,4-Bis(2-ethylhexyloxy)-1,4-dioxo-2-butansulfonsaeure decrease milk supply in lactating mothers?

Anionic surfactant that acts as an emollient laxative. It is also used to treat the retention of ear cerumen. It is minimally absorbed in the duodenum-jejunum and excreted in the bile. No problems have been observed in infants whose mothers were treated, except one case of diarrhea that was possibly due to other laxative medication took by the mother (Greenhalf 1973). The Institute at the American Gastroenterological Association (AGA) consideres it to be compatible while breastfeeding (Mahadevan 2006).

1,4-Bis(2-ethylhexyloxy)-1,4-dioxo-2-butansulfonsaeure is minimally absorbed from the gastrointestinal tract and therefore the drug is unlikely to be found in the maternal serum or breastmilk. Laxatives that are completely unabsorbed may be preferred.[2]

In a randomized, blinded trial, 35 postpartum breastfeeding patients received a laxative containing 1,4-Bis(2-ethylhexyloxy)-1,4-dioxo-2-butansulfonsaeure in a dose of 120 mg daily in addition to danthron 100 mg daily. One patient stated that diarrhea occurred in her breastfed infant.[1] The diarrhea was most likely caused by the danthron.