Is Amantadine Hydrochloride Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Amantadine Hydrochloride? Is Amantadine Hydrochloride safe for nursing mother and child? Does Amantadine Hydrochloride extracts into breast milk? Does Amantadine Hydrochloride has any long term or short term side effects on infants? Can Amantadine Hydrochloride influence milk supply or can Amantadine Hydrochloride decrease milk supply in lactating mothers?
Amantadine Hydrochloride lactation summary
- DrLact safety Score for Amantadine Hydrochloride is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Amantadine Hydrochloride may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Amantadine Hydrochloride may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Amantadine Hydrochloride low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Amantadine Hydrochloride We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Amantadine Hydrochloride usage in lactation
Antiviral used for treatment and prophylaxis of type-A Influenza. Since it is a dopamine agonist is also used to treat Parkinson’s disease. At latest update relevant published data on excretion into breast milk were not found. Because of large volume of distribution and low plasma level observed (Pacifici 1976), a passage of significant amount through breastmilk or side-effects on the infant are not likely to occur. Amantadine reduces plasma levels of prolactin, it has been used to treat galactorrhea caused by the use of dopaminergic neuroleptic drugs (Siever 1981 Correa 1987, Marken 1992, Carvalho 2011), however there is not information about the effect on lactating mothers. Prolactin is important to milk production especially during the first few weeks within birth. Frequent and effective stimulation of the nipple by the infant is essential on the maintenance of breastfeeding. Whether administered during breastfeeding, it would be advisable not to use it in the neonatal period and monitor milk production.
Answer by DrLact: About Amantadine Hydrochloride usage in lactation
It is probably best to avoid amantadine during breastfeeding because of its potential negative effect on lactation.
Amantadine Hydrochloride Possible Effects in Breastfeeding
Amantadine is a dopamine agonist. Clinical studies using amantadine dosages of 100 mg 2 or 3 times daily have demonstrated a decrease in serum prolactin and decreased galactorrhea in patients taking dopaminergic neuroleptic drugs such as phenothiazines, haloperidol and loxapine.[1][2] No studies have been reported on the effects of amantadine on the milk supply in nursing mothers. The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs for Anti-parkinson drugs: Anticholinergics & Dopaminergic agents. ATC N04
Amantadine(Low Risk)
Bromocriptine(Unsafe)
Levodopa(Unsafe)
Ropinirole(Unsafe)
Pramipexole(Unsafe)
Apomorphine-Hydrochloride(Low Risk)
Biperiden(Unsafe)
Bromocriptine Mesilate(Unsafe)
Carbidopa(Low Risk)
Orphenadrine(Low Risk)
Procyclidine(Unsafe)
Rasagiline(Dangerous)
Ropinirole Hydrochloride(Unsafe)
Orphenadrine Citrate(Low Risk)
L-Dopa(Unsafe)