Is Orphenadrine Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Orphenadrine? Is Orphenadrine safe for nursing mother and child? Does Orphenadrine extracts into breast milk? Does Orphenadrine has any long term or short term side effects on infants? Can Orphenadrine influence milk supply or can Orphenadrine decrease milk supply in lactating mothers?
Orphenadrine lactation summary
- DrLact safety Score for Orphenadrine is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Orphenadrine may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Orphenadrine may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Orphenadrine low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Orphenadrine We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Orphenadrine usage in lactation
Anti-muscarinic analogue agent similar to Diphenhydramine with no sedative effect. Used for the treatment of muscle spasms and Parkinson Disease. At latest update, relevant published data on excretion into breast milk were not found. Its pharmacokinetics (moderately high molecular weight and high protein-binding capacity) makes excretion into breast milk in significant amount be unlikely. Until more data on this medication is available, safer alternative drugs are preferred especially in premature babies or during the neonatal period. Whenever used while breastfeeding take the lowest dose as possible along with a follow-up for somnolence and troubles of the infant with feeding. It is not commercially available in Spain.
Alternate Drugs for Anti-parkinson drugs: Anticholinergics & Dopaminergic agents. ATC N04
Amantadine(Low Risk)
Bromocriptine(Unsafe)
Levodopa(Unsafe)
Ropinirole(Unsafe)
Pramipexole(Unsafe)
Amantadine Hydrochloride(Low Risk)
Apomorphine-Hydrochloride(Low Risk)
Biperiden(Unsafe)
Bromocriptine Mesilate(Unsafe)
Carbidopa(Low Risk)
Procyclidine(Unsafe)
Rasagiline(Dangerous)
Ropinirole Hydrochloride(Unsafe)
Orphenadrine Citrate(Low Risk)
L-Dopa(Unsafe)