Is MBDZ Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use MBDZ? Is MBDZ safe for nursing mother and child? Does MBDZ extracts into breast milk? Does MBDZ has any long term or short term side effects on infants? Can MBDZ influence milk supply or can MBDZ decrease milk supply in lactating mothers?

Because of a high plasma protein binding capacity, excretion into breast milk seems to be unlikely. A report failed to find any trace of MBDZ in the breast milk. No side effects in breastfed infants from treated mothers have been found. Based on a low oral bioavailability, concentration in the infant's plasma should be nil or low, except in premature and newborn infants with a increased intestinal absorption capacity. Since it has a vermifuge action on Ascaris worms (migration of alive worms) should be carefully used in the tropics, Reportedly, one case of inhibition of mother's milk production was found that was not confirmed in later reports. WHO's Eleventh Model List of Essential Drugs 2002: Compatible with breastfeeding.

Limited data indicate that MBDZ is poorly excreted into breastmilk and poorly absorbed orally. Reports on the use of MBDZ during breastfeeding have found no adverse reactions in breastfed infants. There are rare case reports of a decrease in milk supply following use of MBDZ, but no convincing evidence that these were caused by the drug. No special precautions are required.

A case series reported 45 nursing mothers who took MBDZ in doses ranging from 100 mg once to 200 mg twice daily for 3 days. About half took 100 mg repeated once after 7 to 14 days. Thirty-three of the infants were exclusively breastfed with ages ranging from 1 to 30 weeks of age. Eight of the 12 partially breastfed infants were over 20 weeks of age. None of the infants were reported by their mothers to have had any adverse reactions.[3]

A nursing mother who was 13 weeks postpartum was taking oral metronidazole 250 mg three times daily. Milk production seemed to be unaffected. On the eighth day of therapy she passed a roundworm. Metronidazole was discontinued and oral MBDZ 100 mg twice daily was started. The patient was "tense" for a few days after passing the worm. On the second day of MBDZ treatment, milk production dropped markedly and she began supplementation with formula. By day 7, milk production had ceased. The authors suggested that MBDZ might have caused the drop in milk production, but offered no further evidence other than the temporal relationship.[4] Four patients were treated with oral MBDZ 100 mg twice daily for 3 days beginning the first day postpartum. Two had pinworm (), 1 had roundworm () and 1 had hookworm () infestations. All breastfed successfully.[2] One author reported information received by personal communication from the manufacturer stating that no inhibition of lactation was noted after a single 100 mg oral dose of MBDZ to a nursing mother (time postpartum not stated).[1] In a case series reported 45 nursing mothers who took MBDZ in doses ranging from 100 mg once to 200 mg twice daily for 3 days, one mother reported a slight decrease in milk production.[3]