Question

I am a breastfeeding mother and i want to know if it is safe to use Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate? Is Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate safe for nursing mother and child? Does Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate extracts into breast milk? Does Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate has any long term or short term side effects on infants? Can Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate influence milk supply or can Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate decrease milk supply in lactating mothers?

Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate lactation summary

Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate is safe in breastfeeding
  • DrLact safety Score for Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate usage in lactation

Because of a high plasma protein binding capacity, excretion into breast milk seems to be unlikely. A report failed to find any trace of Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate in the breast milk. No side effects in breastfed infants from treated mothers have been found. Based on a low oral bioavailability, concentration in the infant's plasma should be nil or low, except in premature and newborn infants with a increased intestinal absorption capacity. Since it has a vermifuge action on Ascaris worms (migration of alive worms) should be carefully used in the tropics, Reportedly, one case of inhibition of mother's milk production was found that was not confirmed in later reports. WHO's Eleventh Model List of Essential Drugs 2002: Compatible with breastfeeding.

Answer by DrLact: About Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate usage in lactation

Limited data indicate that Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate is poorly excreted into breastmilk and poorly absorbed orally. Reports on the use of Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate during breastfeeding have found no adverse reactions in breastfed infants. There are rare case reports of a decrease in milk supply following use of Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate, but no convincing evidence that these were caused by the drug. No special precautions are required.

Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate Side Effects in Breastfeeding

A case series reported 45 nursing mothers who took Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate in doses ranging from 100 mg once to 200 mg twice daily for 3 days. About half took 100 mg repeated once after 7 to 14 days. Thirty-three of the infants were exclusively breastfed with ages ranging from 1 to 30 weeks of age. Eight of the 12 partially breastfed infants were over 20 weeks of age. None of the infants were reported by their mothers to have had any adverse reactions.[3]

Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate Possible Effects in Breastfeeding

A nursing mother who was 13 weeks postpartum was taking oral metronidazole 250 mg three times daily. Milk production seemed to be unaffected. On the eighth day of therapy she passed a roundworm. Metronidazole was discontinued and oral Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate 100 mg twice daily was started. The patient was "tense" for a few days after passing the worm. On the second day of Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate treatment, milk production dropped markedly and she began supplementation with formula. By day 7, milk production had ceased. The authors suggested that Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate might have caused the drop in milk production, but offered no further evidence other than the temporal relationship.[4] Four patients were treated with oral Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate 100 mg twice daily for 3 days beginning the first day postpartum. Two had pinworm (), 1 had roundworm () and 1 had hookworm () infestations. All breastfed successfully.[2] One author reported information received by personal communication from the manufacturer stating that no inhibition of lactation was noted after a single 100 mg oral dose of Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate to a nursing mother (time postpartum not stated).[1] In a case series reported 45 nursing mothers who took Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate in doses ranging from 100 mg once to 200 mg twice daily for 3 days, one mother reported a slight decrease in milk production.[3]

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