Is Pirazinamida [INN-Spanish] Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Pirazinamida [INN-Spanish]? Is Pirazinamida [INN-Spanish] safe for nursing mother and child? Does Pirazinamida [INN-Spanish] extracts into breast milk? Does Pirazinamida [INN-Spanish] has any long term or short term side effects on infants? Can Pirazinamida [INN-Spanish] influence milk supply or can Pirazinamida [INN-Spanish] decrease milk supply in lactating mothers?
Pirazinamida [INN-Spanish] lactation summary
![Pirazinamida [INN-Spanish] is safe in breastfeeding](/images/breastfeeding/safe-in-breastfeeding.jpg "Pirazinamida [INN-Spanish] breastfeeding")
- DrLact safety Score for Pirazinamida [INN-Spanish] is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Pirazinamida [INN-Spanish] is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Pirazinamida [INN-Spanish] does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Pirazinamida [INN-Spanish] safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Pirazinamida [INN-Spanish] usage in lactation
We are working on a comment for this product.
Answer by DrLact: About Pirazinamida [INN-Spanish] usage in lactation
Limited information indicates that maternal Pirazinamida [INN-Spanish] therapy produces low levels in milk and would not usually be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Exclusively breastfed infants should be monitored for rare cases of jaundice, hepatitis and arthralgia if this drug is used during lactation.[1] The amount of Pirazinamida [INN-Spanish] in milk is insufficient to treat tuberculosis in the breastfed infant. The Centers for Disease Control and Prevention and other professional organizations state that breastfeeding should not be discouraged in women taking Pirazinamida [INN-Spanish].[2][3][4]
Pirazinamida [INN-Spanish] Side Effects in Breastfeeding
Pirazinamida [INN-Spanish] was used as part of multi-drug regimens to treat 2 pregnant women with multidrug-resistant tuberculosis throughout pregnancy and postpartum. Their two infants were breastfed (extent and duration not stated). At age 1.25 and 5.1 years, the children were developing normally.[5] Two mothers in Turkey were diagnosed with tuberculosis at the 30th and 34th weeks of pregnancy. They immediately started isoniazid 300 mg, rifampin 600 mg, pyridoxine 50 mg daily for 6 months, plus Pirazinamida [INN-Spanish] 25 mg/kg and ethambutol 25 mg/kg daily for 2 months. Both mothers breastfed their infants (extent not stated). Their infants were given isoniazid 5 mg/kg daily for 3 months prophylactically. Tuberculin skin tests were negative after 3 months and neither infant had tuberculosis at 1 year of age. No adverse effects of the drugs were mentioned.[6]
Alternate Drugs
Streptomycin(Safe)
Rifabutin(Low Risk)
Capreomycin(Low Risk)
Rifampin(Safe)
Pyrazinamide(Safe)
Isoniazid(Safe)