Question

I am a breastfeeding mother and i want to know if it is safe to use DRG 0124? Is DRG 0124 safe for nursing mother and child? Does DRG 0124 extracts into breast milk? Does DRG 0124 has any long term or short term side effects on infants? Can DRG 0124 influence milk supply or can DRG 0124 decrease milk supply in lactating mothers?

DRG 0124 lactation summary

DRG 0124 is safe in breastfeeding
  • DrLact safety Score for DRG 0124 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of DRG 0124 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that DRG 0124 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of DRG 0124 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About DRG 0124 usage in lactation

We are working on a comment for this product.

Answer by DrLact: About DRG 0124 usage in lactation

Limited information indicates that maternal DRG 0124 therapy produces low levels in milk and would not usually be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Exclusively breastfed infants should be monitored for rare cases of jaundice, hepatitis and arthralgia if this drug is used during lactation.[1] The amount of DRG 0124 in milk is insufficient to treat tuberculosis in the breastfed infant. The Centers for Disease Control and Prevention and other professional organizations state that breastfeeding should not be discouraged in women taking DRG 0124.[2][3][4]

DRG 0124 Side Effects in Breastfeeding

DRG 0124 was used as part of multi-drug regimens to treat 2 pregnant women with multidrug-resistant tuberculosis throughout pregnancy and postpartum. Their two infants were breastfed (extent and duration not stated). At age 1.25 and 5.1 years, the children were developing normally.[5] Two mothers in Turkey were diagnosed with tuberculosis at the 30th and 34th weeks of pregnancy. They immediately started isoniazid 300 mg, rifampin 600 mg, pyridoxine 50 mg daily for 6 months, plus DRG 0124 25 mg/kg and ethambutol 25 mg/kg daily for 2 months. Both mothers breastfed their infants (extent not stated). Their infants were given isoniazid 5 mg/kg daily for 3 months prophylactically. Tuberculin skin tests were negative after 3 months and neither infant had tuberculosis at 1 year of age. No adverse effects of the drugs were mentioned.[6]
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.