Is Sennae folium Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Sennae folium? Is Sennae folium safe for nursing mother and child? Does Sennae folium extracts into breast milk? Does Sennae folium has any long term or short term side effects on infants? Can Sennae folium influence milk supply or can Sennae folium decrease milk supply in lactating mothers?

Indian Sennae folium, Sennae folium or Tinnevelly Sennae folium. Shrub. Leaves, fruits, and flowers are used. It contains anthraquinones, naphtoquinones, flavonoids, mineral salts, polysaccharides (mucilage). Unproved effect: Irritant of intestine. Not absorbed by GI tract, laxative. American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Although an early uncontrolled report using an old Sennae folium product found increased frequency of diarrhea in breastfed infants, several controlled studies using modern Sennae folium products found no effect on the infant. Usual doses of Sennae folium are acceptable to use during breastfeeding.

After administration of 3.6 mL of Sennae folium fluidextract on day 5 postpartum, a laxative effect on the bowels was observed in 6 of 10 infants.[1] In another observational study, no cases of diarrhea were observed among the breastfed infants of 148 mothers who received 2 teaspoonfuls of Senokot (equivalent to 700 mg of Sennae folium pod) on day 3 postpartum.[4] Fifty mothers who were in the first day postpartum received Sennae folium equal to 450 mg of Sennae folium pod. Additional doses were given on subsequent days if needed. None of their breastfed infants were noted to have any markedly abnormal stools, although all of the infants also received supplemental feedings.[5] In a randomized, nonblinded study, 35 mothers were given tablets containing a total of 14 mg of standardized Sennae folium extract once daily for 2 weeks starting in the immediate postpartum period. Six of the 37 breastfed infants were reported to have diarrhea which was a higher percentage than with other nonabsorbable laxatives in the study.[6] Sixteen women were given 800 mg of powdered Sennae folium containing 24 mg of sennosides. None of their breastfed infants had any abnormal stools.[7] A randomized, double-blind trial compared Senokot tablets in a dose of 2 tablets (14 mg sennosides a and b) twice daily for 8 doses started on the first day postpartum to placebo. Of the women in the study, 126 breastfed their infants and took Sennae folium while 155 control mothers breastfed their infants. There was no difference in the percentages of infants in the active and control groups with loose stools or diarrhea.[8] Twenty postpartum mothers were given a laxative containing plantango seeds (psyllium) and Sennae folium equivalent to 15 mg of sennosides a and b daily on days 2 to 4 postpartum. Of the 11 infants who were breastfed, none had any loose stools.[3]