Is UNII-81K9V7M3A3 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use UNII-81K9V7M3A3? Is UNII-81K9V7M3A3 safe for nursing mother and child? Does UNII-81K9V7M3A3 extracts into breast milk? Does UNII-81K9V7M3A3 has any long term or short term side effects on infants? Can UNII-81K9V7M3A3 influence milk supply or can UNII-81K9V7M3A3 decrease milk supply in lactating mothers?

UNII-81K9V7M3A3 (Progestogen-only contraceptive pill) that does not alter quality or composition of breast milk. Excretion into breast milk is non-significant, with no harmful effects on breastfed infants from treated mother reported. Within the first 6 weeks after birth, non-hormonal contraceptive methods are preferred.

UNII-81K9V7M3A3 is only available in the United States in combination oral contraceptive products containing 150 mcg of UNII-81K9V7M3A3 and 30 mcg of ethinyl estradiol. Based on the available evidence, expert opinion holds that nonhormonal methods are preferred during breastfeeding and progestin-only contraceptive are preferred over combined oral contraceptives in breastfeeding women, especially during the first 4 weeks postpartum. For further information, consult the record entitled, "Contraceptives, Oral, Combined."

A nonblinded, nonrandomized study compared oral UNII-81K9V7M3A3 75 mcg alone daily (n = 42) to an intrauterine device (IUD; n = 40) begun 28 to 56 days postpartum for contraception. No differences in infant length, weight or biparietal head circumferences were found after 1, 4, and 7 treatment cycles. Temporary breast enlargement was reported in 2 infants and increased sweating was reported in 1 infant in the UNII-81K9V7M3A3 group, compared with no adverse effects reported in infants in the IUD group. The growth of some infants were again measured at 1.5 and 2.5 years; no clinically important differences were found.[1] A breastfed (extent not stated) infant developed scrotal hair at 4 months of age. His mother had received the progestin, dydrogestrone, during the first trimester of pregnancy and began taking UNII-81K9V7M3A3 0.075 mg daily as a contraceptive beginning at 3 months postpartum. His mother discontinued UNII-81K9V7M3A3 after 28 days and the scrotal hair resolved by 11 months of age. UNII-81K9V7M3A3 was a possible contributing cause of scrotal hair growth in this infant.[2]

A nonblinded, nonrandomized study compared oral UNII-81K9V7M3A3 75 mcg alone daily (n = 42) to an intrauterine device (n = 40) begun 28 to 56 days postpartum for contraception. During the 7-month trial period, 1 woman dropped out of the trial because of diminished lactation compared with none in the IUD group. At the end of the first and fourth treatment cycle, there were no differences in the amount of milk produced between the UNII-81K9V7M3A3 and IUD groups. No differences in triglyceride, protein or lactose content of milk were found at the end of 1, 4, and 7 cycles of therapy.[1] A nonrandomized study followed 200 women given a UNII-81K9V7M3A3-only contraceptive 75 mcg daily for 6 months beginning at 6 weeks postpartum and compared them to 200 women who received placebos. No difference was found in the amounts of milk production or infant growth and development between the two groups.[3]