Is Diltiazem Hydrochloride Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Diltiazem Hydrochloride? Is Diltiazem Hydrochloride safe for nursing mother and child? Does Diltiazem Hydrochloride extracts into breast milk? Does Diltiazem Hydrochloride has any long term or short term side effects on infants? Can Diltiazem Hydrochloride influence milk supply or can Diltiazem Hydrochloride decrease milk supply in lactating mothers?
Diltiazem Hydrochloride lactation summary
- DrLact safety Score for Diltiazem Hydrochloride is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Diltiazem Hydrochloride is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Diltiazem Hydrochloride does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Diltiazem Hydrochloride safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Diltiazem Hydrochloride usage in lactation
It is excreted in breast milk in a clinically non-significant amount (Okada 85)Two 6 months-old breastfed twins whose mother was treated with diltiazem did not get into health problems (Lubbe 87) Evidence on other antihypertensive drugs of the same family with similar structure, pharmacokinetics and action profile (nifedipine, nimodipine, nicardipine) has shown that they are excreted into milk in non-significant amount.Diltiazem does not have any influence on prolactin production. Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug should be used, especially during the neonatal period and/or in case of premature infants. American Academy of Pediatrics: medication usually compatible with breastfeeding.
Answer by DrLact: About Diltiazem Hydrochloride usage in lactation
Based on limited data, amounts of diltiazem ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.
Alternate Drugs for Anti-hypertensive Calcium channel-Blocker. ATC C08
Amlodipine(Low Risk)
Diltiazem(Safe)
Felodipine(Low Risk)
Isradipine(Low Risk)
Nifedipine(Safe)
Nimodipine(Safe)
Nisoldipine(Low Risk)
Nitrendipine(Safe)
Verapamil(Safe)
Nicardipine(Safe)
Amlodipine Besylate(Low Risk)
Verapamil Hydrochloride(Safe)
Bepridil Hydrochloride(Unsafe)
Lercanidipine Hydrochloride(Low Risk)
Manidipine Hydrochloride(Low Risk)